Dog · Canis lupus familiaris · typical adult weight 2.00–80.00 kg
Phenoxybenzamine is dosed at 0.25–1.5 mg/kg PO q12h in dogs, per Volker L. An evaluation of the effectiveness of phenoxybenzamine HCI (Dibenzyline) in horses under field conditions. Internal Smith Kline and French Report;1984. — Verified against Plumb's Veterinary Drug Handbook, 10th Ed, p.1039 (2026-08-01). — Plumb's 10th ed (held) printed p.1011, Phenoxybenzamine monograph spanning p.1011-1012; page located 2026-08-05 from the book's own running heads, verified to name the drug in its body text. — SOURCE EDITION: Plumb's Veterinary Drug Handbook — ISBN 9781394172207, https://openlibrary.org/isbn/9781394172207 — Plumb's Veterinary Drug Handbook, 10th ed (held), Phenoxybenzamine monograph, printed p.1012 (corpus PDF p.1039), DOGS: "Hypertension associated with pheochromocytoma (extra-label): Initially 0.25 - 0.5 mg/kg PO every 12 […]" [INDICATION NARROWED 2026-08-12, two readers — the printed canine functional-urethral-obstruction figure on the same page is 0.25 mg/kg PO q12h, six times below this row's ceiling.]. Phenoxybenzamine is used in dogs for Hypertension associated with pheochromocytoma (preoperative). Routes documented in dogs: PO. A typical adult dog weighs 2.00–80.00 kg. ExoticRx lists 1 cited dose rule for Phenoxybenzamine in dogs, drawn from published veterinary references. Verify against current literature before clinical use.
US trade names: Dibenzyline
| Route | Dose | Frequency | Duration | Indication | Evidence | Source |
|---|---|---|---|---|---|---|
| PO | 0.25–1.5 mg/kg | q12h | Variable | Hypertension associated with pheochromocytoma (preoperative) | Moderate | Volker L. An evaluation of the effectiveness of phenoxybenzamine HCI (Dibenzyline) in horses under field conditions. Internal Smith Kline and French Report;1984. — Verified against Plumb's Veterinary Drug Handbook, 10th Ed, p.1039 (2026-08-01). — Plumb's 10th ed (held) printed p.1011, Phenoxybenzamine monograph spanning p.1011-1012; page located 2026-08-05 from the book's own running heads, verified to name the drug in its body text. — SOURCE EDITION: Plumb's Veterinary Drug Handbook — ISBN 9781394172207, https://openlibrary.org/isbn/9781394172207 — Plumb's Veterinary Drug Handbook, 10th ed (held), Phenoxybenzamine monograph, printed p.1012 (corpus PDF p.1039), DOGS: "Hypertension associated with pheochromocytoma (extra-label): Initially 0.25 - 0.5 mg/kg PO every 12 […]" [INDICATION NARROWED 2026-08-12, two readers — the printed canine functional-urethral-obstruction figure on the same page is 0.25 mg/kg PO q12h, six times below this row's ceiling.] |
Every held source for this drug and species, as printed. Where they differ, both are shown — the choice is yours, not ours.
The sources disagree for this combination. The ranges below do not overlap on a comparable route. This is not an error in one of them — published veterinary references differ, and reconciling them for a particular patient is a clinical judgement.
| Dose (mg/kg) | Route | Source | As printed |
|---|---|---|---|
| 0.25–1 | PO | BSAVA Small Animal Formulary, 10th ed — Part A (Canine and Feline)p.333 | 0.25-1 mg/kg p.o. q8-24h for a minimum of 5 days. • Hypertension associated with phaeochromoc |
| 0.25–0.5 | PO | BSAVA Small Animal Formulary, 10th ed — Part A (Canine and Feline)p.333 | days. • Hypertension associated with phaeochromocytoma: 0.25-0.5 mg/kg p.o. q12h for 10-14 days prior to surgery, titrating up to 318 BSAVA Small Animal Form |
| 2.5 | — | BSAVA Small Animal Formulary, 10th ed — Part A (Canine and Feline)p.334 | Canine and Feline an effective dose (maximum of 2.5 mg/kg q12h) as required or administer long term for medical management if adrenalectomy |
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Irreversible non-selective alpha-adrenergic blocker. Causes long-lasting vasodilation and reduces urethral smooth muscle tone.
Used for pheochromocytoma, urethral spasm, and functional urethral obstruction. Hypotension common. Effects last 3-4 days after stopping (irreversible binding). Nasal congestion.
Species-specific contraindications and adverse-reaction reports for dogs may differ from canine / feline reference data — consult the primary citations listed with each rule.
Phenoxybenzamine dose range in dogs, with cited source references: PO 0.25–1.5 mg/kg q12h. Reference ranges from cited sources — verify against current literature before clinical use.
Documented routes for Phenoxybenzamine in dogs: PO.
Cited course lengths for Phenoxybenzamine in dogs include: Variable. Duration depends on the indication — match it to the specific dose rule in the table above.
Phenoxybenzamine is indicated in dogs for: Hypertension associated with pheochromocytoma (preoperative).
These are general warnings for Phenoxybenzamine across species; consult the dog dosing table above for species-specific guidance. Used for pheochromocytoma, urethral spasm, and functional urethral obstruction. Hypotension common. Effects last 3-4 days after stopping (irreversible binding). Nasal congestion.
Why a species-specific page? Phenoxybenzamine pharmacokinetics differ across species: dose ranges, intervals, and route preferences are not interchangeable. Cross-extrapolation from canine doses is unsafe in dogs — the rules above are the citations specific to this species, not generic recommendations.
Sourced from published veterinary references; awaiting credentialed clinical reviewer. See our editorial process. Reference only — not veterinary advice.
| 0.25 | PO | Papich Saunders Handbook of Veterinary Drugs, 4th edp.655 | • 0.25 mg/kg q8-12h or 0.5 mg/kg q24h PO. |
| 0.5 | PO | Papich Saunders Handbook of Veterinary Drugs, 4th edp.655 | • 0.25 mg/kg q8-12h or 0.5 mg/kg q24h PO. |
| 0.6 | — | Papich Saunders Handbook of Veterinary Drugs, 4th edp.655 | • For presurgical treatment of pheochromocytoma: 0.6 mg/kg q12h (range is |
| 1–2 | — | Papich Saunders Handbook of Veterinary Drugs, 4th edp.655 | 1-2 mg/kg/day), given 2 weeks prior to surgery to stabilize blood pressure. |
Figures are transcribed from the cited page or table of each held edition and are shown for reference only. They are not dose recommendations, they do not feed the calculator, and none has been reviewed by a veterinarian.