ExoticRx · exoticrx.com/drugs/phenoxybenzamine
US brand names:Dibenzyline
Phenoxybenzamine is dosed at 0.25 mg/kg PO q12h in guinea pigs, per Mans C. Personal communication; 2016. — Source: Carpenter's Exotic Animal Formulary, 6th Ed, p.802 — Carpenter's Exotic Animal Formulary 6th ed, Table 9.7 (Miscellaneous Agents Used in Rodents). Verify against current literature before clinical use.
Irreversible non-selective alpha-adrenergic blocker. Causes long-lasting vasodilation and reduces urethral smooth muscle tone.
Used for pheochromocytoma, urethral spasm, and functional urethral obstruction. Hypotension common. Effects last 3-4 days after stopping (irreversible binding). Nasal congestion.
Species references:All Cat (Domestic) drugsAll Dog (Domestic) drugsAll Ferret drugsAll Guinea Pig drugs
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A dog/cat sample is shown here. Cited dosing for all 4 species — reptiles, birds, pocket pets, livestock, and equine — is free on the per-species pages above. Pro adds the weight-based calculator for every species.
| Species | Route | Dose | Frequency | Evidence | Source |
|---|---|---|---|---|---|
| Dog (Domestic) | PO | 0.25–1.5 mg/kg | q12h | Moderate | Volker L. An evaluation of the effectiveness of phenoxybenzamine HCI (Dibenzyline) in horses under field conditions. Internal Smith Kline and French Report;1984. — Plumb's 10th ed printed p.1011, Phenoxybenzamine monograph spanning p.1011-1012. — Plumb's Veterinary Drug Handbook, 10th ed, Phenoxybenzamine monograph, printed p.1012, DOGS: "Hypertension associated with pheochromocytoma (extra-label): Initially 0.25 - 0.5 mg/kg PO every 12 […]"Compilation only — we have not located an independent source that prints this figure. |
| Cat (Domestic) | PO | 0.5–1 mg/kg | q12h | Weak | BSAVA Small Animal Formulary, 10th ed. (2020), Part A - Canine and Feline, p.318 (PDF 334), Phenoxybenzamine — DOSES, CatsCompilation only — we have not located an independent source that prints this figure. |
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View PlansSource citations and evidence levels available on the live page. Reference only — verify against current literature before clinical use.