ExoticRx · exoticrx.com/drugs/phenoxybenzamine
US brand names:Dibenzyline
Phenoxybenzamine is dosed at 0.5–1 mg/kg PO q12h in cats, per BSAVA Small Animal Formulary, 10th ed. (2020), Part A - Canine and Feline, p.318 (PDF 334), Phenoxybenzamine — DOSES, Cats. Verify against current literature before clinical use.
Irreversible non-selective alpha-adrenergic blocker. Causes long-lasting vasodilation and reduces urethral smooth muscle tone.
Used for pheochromocytoma, urethral spasm, and functional urethral obstruction. Hypotension common. Effects last 3-4 days after stopping (irreversible binding). Nasal congestion.
Species references:All Cat (Domestic) drugsAll Dog (Domestic) drugs
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A dog/cat sample is shown here. Cited dosing for all 2 species — reptiles, birds, pocket pets, livestock, and equine — is free on the per-species pages above. Pro adds the weight-based calculator for every species.
| Species | Route | Dose | Frequency | Evidence | Source |
|---|---|---|---|---|---|
| Cat (Domestic) | PO | 0.5–1 mg/kg | q12h | Moderate | BSAVA Small Animal Formulary, 10th ed. (2020), Part A - Canine and Feline, p.318 (PDF 334), Phenoxybenzamine — DOSES, Cats |
| Dog (Domestic) | PO | 0.25–1.5 mg/kg | q12h | Moderate | Volker L. An evaluation of the effectiveness of phenoxybenzamine HCI (Dibenzyline) in horses under field conditions. Internal Smith Kline and French Report;1984. — Verified against Plumb's Veterinary Drug Handbook, 10th Ed, p.1039 (2026-08-01). |
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View PlansSource citations and evidence levels available on the live page. Reference only — verify against current literature before clinical use.