ExoticRx · exoticrx.com/drugs/phenoxybenzamine
US brand names:Dibenzyline
Phenoxybenzamine is dosed at 0.5–1 mg/kg PO q12h in ferrets, per Hedley J. Small Animal Formulary-Part B: Exotic Pets, 10th ed., British Small Animal Veterinary Association, Gloucester, UK; 2020. — Source: Carpenter's Exotic Animal Formulary, 6th Ed, p.957 — Carpenter's Exotic Animal Formulary 6th ed, Table 11.10 (Miscellaneous Agents Used in Ferrets.a). The copy held is an ebook conversion with no printed page numbers, so the table — not the page — is the citable location. — SOURCE EDITION: Carpenter's Exotic Animal Formulary — ISBN 9780323833929, https://openlibrary.org/isbn/9780323833929. Verify against current literature before clinical use.
Irreversible non-selective alpha-adrenergic blocker. Causes long-lasting vasodilation and reduces urethral smooth muscle tone.
Used for pheochromocytoma, urethral spasm, and functional urethral obstruction. Hypotension common. Effects last 3-4 days after stopping (irreversible binding). Nasal congestion.
Species references:All Cat (Domestic) drugsAll Dog (Domestic) drugsAll Ferret drugsAll Guinea Pig drugs
Each ExoticRx dose rule is graded by the strength of its primary evidence — see the editorial process.
A dog/cat sample is shown here. Cited dosing for all 4 species — reptiles, birds, pocket pets, livestock, and equine — is free on the per-species pages above. Pro adds the weight-based calculator for every species.
| Species | Route | Dose | Frequency | Evidence | Source |
|---|---|---|---|---|---|
| Dog (Domestic) | PO | 0.25–1.5 mg/kg | q12h | Moderate | Volker L. An evaluation of the effectiveness of phenoxybenzamine HCI (Dibenzyline) in horses under field conditions. Internal Smith Kline and French Report;1984. — Verified against Plumb's Veterinary Drug Handbook, 10th Ed, p.1039 (2026-08-01). — Plumb's 10th ed (held) printed p.1011, Phenoxybenzamine monograph spanning p.1011-1012; page located 2026-08-05 from the book's own running heads, verified to name the drug in its body text. — SOURCE EDITION: Plumb's Veterinary Drug Handbook — ISBN 9781394172207, https://openlibrary.org/isbn/9781394172207 — Plumb's Veterinary Drug Handbook, 10th ed (held), Phenoxybenzamine monograph, printed p.1012 (corpus PDF p.1039), DOGS: "Hypertension associated with pheochromocytoma (extra-label): Initially 0.25 - 0.5 mg/kg PO every 12 […]" [INDICATION NARROWED 2026-08-12, two readers — the printed canine functional-urethral-obstruction figure on the same page is 0.25 mg/kg PO q12h, six times below this row's ceiling.] |
| Cat (Domestic) | PO | 0.5–1 mg/kg | q12h |
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| BSAVA Small Animal Formulary, 10th ed. (2020), Part A - Canine and Feline, p.318 (PDF 334), Phenoxybenzamine — DOSES, Cats — LOCATOR CONVENTION 2026-08-07: 'p.318' is the PRINTED page number, confirmed by finding the drug named on it in the held copy. — SOURCE EDITION: BSAVA Small Animal Formulary, Part A — Canine and Feline — ISBN 9781910443705, https://openlibrary.org/isbn/9781910443705 |