Dog · Canis lupus familiaris · typical adult weight 2.00–80.00 kg
Phentolamine is dosed at 0.02–0.1 mg/kg IV IV bolus, repeat q5min as needed in dogs, per Papich, Saunders Handbook of Veterinary Drugs, Phentolamine Mesylate monograph, Instructions for Use: "Results of clinical studies in animals have not been reported. Use in animals (and doses) is based on experience in people or anecdotal experience in animals. Titrate dose for eachttpatient to produce desired vasodilation." PMID: 42418148 — Verified against Papich/Saunders Handbook of Veterinary Drugs, 4th Ed, p.657 (2026-08-01).. Phentolamine is used in dogs for Pheochromocytoma crisis, catecholamine extravasation. Routes documented in dogs: IV. A typical adult dog weighs 2.00–80.00 kg. ExoticRx lists 1 cited dose rule for Phentolamine in dogs, drawn from published veterinary references. Verify against current literature before clinical use.
US trade names: Regitine, OraVerse
| Route | Dose | Frequency | Duration | Indication | Evidence | Source |
|---|---|---|---|---|---|---|
| IV | 0.02–0.1 mg/kg | IV bolus, repeat q5min as needed | Emergency | Pheochromocytoma crisis, catecholamine extravasation | Moderate | Papich, Saunders Handbook of Veterinary Drugs, Phentolamine Mesylate monograph, Instructions for Use: "Results of clinical studies in animals have not been reported. Use in animals (and doses) is based on experience in people or anecdotal experience in animals. Titrate dose for eachttpatient to produce desired vasodilation." PMID: 42418148 — Verified against Papich/Saunders Handbook of Veterinary Drugs, 4th Ed, p.657 (2026-08-01). |
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Competitive non-selective alpha-adrenergic antagonist causing vasodilation. Short-acting compared to phenoxybenzamine.
Used for hypertensive crisis (pheochromocytoma) and treatment of catecholamine extravasation. Tachycardia, hypotension. Short duration of action.
Species-specific contraindications and adverse-reaction reports for dogs may differ from canine / feline reference data — consult the primary citations listed with each rule.
Phentolamine dose range in dogs, with cited source references: IV 0.02–0.1 mg/kg IV bolus, repeat q5min as needed. Reference ranges from cited sources — verify against current literature before clinical use.
Documented routes for Phentolamine in dogs: IV.
Cited course lengths for Phentolamine in dogs include: Emergency. Duration depends on the indication — match it to the specific dose rule in the table above.
Phentolamine is indicated in dogs for: Pheochromocytoma crisis, catecholamine extravasation.
These are general warnings for Phentolamine across species; consult the dog dosing table above for species-specific guidance. Used for hypertensive crisis (pheochromocytoma) and treatment of catecholamine extravasation. Tachycardia, hypotension. Short duration of action.
Why a species-specific page? Phentolamine pharmacokinetics differ across species: dose ranges, intervals, and route preferences are not interchangeable. Cross-extrapolation from canine doses is unsafe in dogs — the rules above are the citations specific to this species, not generic recommendations.
Sourced from published veterinary references; awaiting credentialed clinical reviewer. See our editorial process. Reference only — not veterinary advice.