Prazosin for Dog
Dog · Canis lupus familiaris · typical adult weight 2.00–80.00 kg
Prazosin is used in dog for Urethral relaxation, CHF afterload reduction. Routes documented in dog: PO. A typical adult dog weighs 2.00–80.00 kg. ExoticRx lists 1 cited dose rule for Prazosin in dog, drawn from published veterinary references. Verify against current literature before clinical use.
Trade names: Minipress
Dose ranges
| Route | Dose | Frequency | Duration | Indication | Evidence | Source |
|---|---|---|---|---|---|---|
| PO | 0.5–2 mg/kg | q8-12h | Variable | Urethral relaxation, CHF afterload reduction | Moderate | Plumb's Veterinary Drug Handbook, 9th Ed |
Absolute dose ceiling, regardless of body weight: 15 mg total (PO).
Need the exact dose for your patient?
These ranges are per kg. Enter your dog's weight to get the precise dose and draw-up volume — unit and concentration math done for you.
Mechanism of action
Selective alpha-1 adrenergic blocker causing arterial and venous vasodilation. Also relaxes urethral smooth muscle and prostatic capsule.
Side effects & warnings
First-dose syncope (start low). Used for urethral relaxation, systemic hypertension, and heart failure afterload reduction. Reflex tachycardia possible.
Species-specific contraindications and adverse-reaction reports for dog may differ from canine / feline reference data — consult the primary citations listed with each rule.
Other Cardiovascular drugs with dog dosing
Prazosin dosing in other species
Why a species-specific page? Prazosin pharmacokinetics differ across species: dose ranges, intervals, and route preferences are not interchangeable. Cross-extrapolation from canine doses is unsafe in dog — the rules above are the citations specific to this species, not generic recommendations.
Sourced from published veterinary references; awaiting credentialed clinical reviewer. See our editorial process. Reference only — not veterinary advice.