ExoticRx · exoticrx.com/drugs/prednisolone-oral
US brand names:Prednis-Tab
Prednisolone Oral is dosed at 0.5–1 mg/kg PO q12-24h in dogs, per Plumb's Veterinary Drug Handbook, 9th Ed. Verify against current literature before clinical use.
Active glucocorticoid (does not require hepatic conversion unlike prednisone). Preferred in cats (poor prednisone-to-prednisolone conversion).
Preferred over prednisone in cats and patients with hepatic disease. Same side effects as other glucocorticoids: PU/PD, polyphagia, iatrogenic Cushing's.
Species references:All Cat (Domestic) drugsAll Dog (Domestic) drugs
Each ExoticRx dose rule is graded by the strength of its primary evidence — see the editorial process.
A dog/cat sample is shown here. Cited dosing for all 2 species — reptiles, birds, pocket pets, livestock, and equine — is free on the per-species pages above. Pro adds the weight-based calculator for every species.
| Species | Route | Dose | Frequency | Evidence | Source |
|---|---|---|---|---|---|
| Dog (Domestic) | PO | 0.5–1 mg/kg | q12-24h | Strong | Plumb's Veterinary Drug Handbook, 9th Ed |
| Cat (Domestic) | PO | 1–4 mg/kg | q12-24h, taper over weeks | Strong | Reusch CE. Glucocorticoid therapy. In: Feldman E, Nelson R, Reusch C, Scott-Moncrieff J, Behrend E, eds. Canine and Feline Endocrinology. 4th ed. Elsevier Saunders; 2015:555-577. / 24. Blois SL, Mathews K. Anti-inflammatory therapy. In: Ettinger S, Feldman B, Cote E, eds. Textbook of Veterinary Internal Medicine. 8th ed. Elsevier; 2017:695-700. — Verified against Plumb's Veterinary Drug Handbook, 10th Ed, p.1088 (2026-08-01). |
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View PlansSource citations and evidence levels available on the live page. Reference only — verify against current literature before clinical use.