Dog · Canis lupus familiaris · typical adult weight 2.00–80.00 kg
Pregabalin is dosed at 2–4 mg/kg PO q8-12h in dogs, per Sanchis-Mora S, Chang YM, Abeyesinghe SM, et al. Pregabalin for the treatment of syringomyelia-associated neuropathic pain in dogs: A randomised, placebo-controlled, double-masked clinical trial. Vet J. 2019;250:55-62. doi:10.1016/j.tvjl.2019.06.006 — Verified against Plumb's Veterinary Drug Handbook, 10th Ed, p.1092 (2026-08-01).. Pregabalin is used in dogs for Neuropathic pain, seizures (adjunct). Routes documented in dogs: PO. A typical adult dog weighs 2.00–80.00 kg. ExoticRx lists 1 cited dose rule for Pregabalin in dogs, drawn from published veterinary references. Verify against current literature before clinical use.
US trade names: Lyrica
| Route | Dose | Frequency | Duration | Indication | Evidence | Source |
|---|---|---|---|---|---|---|
| PO | 2–4 mg/kg | q8-12h | Long-term; taper to discontinue | Neuropathic pain, seizures (adjunct) | Moderate | Sanchis-Mora S, Chang YM, Abeyesinghe SM, et al. Pregabalin for the treatment of syringomyelia-associated neuropathic pain in dogs: A randomised, placebo-controlled, double-masked clinical trial. Vet J. 2019;250:55-62. doi:10.1016/j.tvjl.2019.06.006 — Verified against Plumb's Veterinary Drug Handbook, 10th Ed, p.1092 (2026-08-01). |
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These ranges are per kg. Enter your dog's weight to get the precise dose and draw-up volume — unit and concentration math done for you.
Binds alpha-2-delta subunit of voltage-gated calcium channels with higher affinity than gabapentin. Reduces excitatory neurotransmitter release. More predictable pharmacokinetics than gabapentin.
Controlled substance (CV). Sedation and ataxia at higher doses. More potent than gabapentin — lower doses needed. Taper to discontinue. Monitor for weight gain.
Species-specific contraindications and adverse-reaction reports for dogs may differ from canine / feline reference data — consult the primary citations listed with each rule.
Pregabalin dose range in dogs, with cited source references: PO 2–4 mg/kg q8-12h. Reference ranges from cited sources — verify against current literature before clinical use.
Documented routes for Pregabalin in dogs: PO.
Cited course lengths for Pregabalin in dogs include: Long-term; taper to discontinue. Duration depends on the indication — match it to the specific dose rule in the table above.
Pregabalin is indicated in dogs for: Neuropathic pain, seizures (adjunct).
These are general warnings for Pregabalin across species; consult the dog dosing table above for species-specific guidance. Controlled substance (CV). Sedation and ataxia at higher doses. More potent than gabapentin — lower doses needed. Taper to discontinue. Monitor for weight gain.
Why a species-specific page? Pregabalin pharmacokinetics differ across species: dose ranges, intervals, and route preferences are not interchangeable. Cross-extrapolation from canine doses is unsafe in dogs — the rules above are the citations specific to this species, not generic recommendations.
Sourced from published veterinary references; awaiting credentialed clinical reviewer. See our editorial process. Reference only — not veterinary advice.