Dog · Canis lupus familiaris · typical adult weight 2.00–80.00 kg
Pregabalin is dosed at 2–4 mg/kg PO q8-12h in dogs, per Sanchis-Mora S, Chang YM, Abeyesinghe SM, et al. Pregabalin for the treatment of syringomyelia-associated neuropathic pain in dogs: A randomised, placebo-controlled, double-masked clinical trial. Vet J. 2019;250:55-62. doi:10.1016/j.tvjl.2019.06.006 — Verified against Plumb's Veterinary Drug Handbook, 10th Ed, p.1092 (2026-08-01). — Plumb's 10th ed (held) printed p.1064, Pregabalin monograph; page located 2026-08-05 from the book's own running heads, verified to name the drug in its body text. — SOURCE EDITION: Plumb's Veterinary Drug Handbook — ISBN 9781394172207, https://openlibrary.org/isbn/9781394172207. Pregabalin is used in dogs for Neuropathic pain, seizures (adjunct). Routes documented in dogs: PO. A typical adult dog weighs 2.00–80.00 kg. ExoticRx lists 1 cited dose rule for Pregabalin in dogs, drawn from published veterinary references. Verify against current literature before clinical use.
US trade names: Lyrica
| Route | Dose | Frequency | Duration | Indication | Evidence | Source |
|---|---|---|---|---|---|---|
| PO | 2–4 mg/kg | q8-12h | Long-term; taper to discontinue | Neuropathic pain, seizures (adjunct) | Moderate | Sanchis-Mora S, Chang YM, Abeyesinghe SM, et al. Pregabalin for the treatment of syringomyelia-associated neuropathic pain in dogs: A randomised, placebo-controlled, double-masked clinical trial. Vet J. 2019;250:55-62. doi:10.1016/j.tvjl.2019.06.006 — Verified against Plumb's Veterinary Drug Handbook, 10th Ed, p.1092 (2026-08-01). — Plumb's 10th ed (held) printed p.1064, Pregabalin monograph; page located 2026-08-05 from the book's own running heads, verified to name the drug in its body text. — SOURCE EDITION: Plumb's Veterinary Drug Handbook — ISBN 9781394172207, https://openlibrary.org/isbn/9781394172207 |
Every held source for this drug and species, as printed. Where they differ, both are shown — the choice is yours, not ours.
| Dose (mg/kg) | Route | Source | As printed |
|---|---|---|---|
| 3–4 | PO | BSAVA Small Animal Formulary, 10th ed — Part A (Canine and Feline)p.357 | 3-4 mg/kg p.o. q8h, starting at 2 mg/kg and gradually increasing. |
| 2 | — | BSAVA Small Animal Formulary, 10th ed — Part A (Canine and Feline)p.357 | 3-4 mg/kg p.o. q8h, starting at 2 mg/kg and gradually increasing. |
| 4 | PO | BSAVA Small Animal Formulary, 10th ed — Part A (Canine and Feline)p.357 | 4 mg/kg p.o. q12h (limited evidence) |
Figures are transcribed from the cited page or table of each held edition and are shown for reference only. They are not dose recommendations, they do not feed the calculator, and none has been reviewed by a veterinarian.
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These ranges are per kg. Enter your dog's weight to get the precise dose and draw-up volume — unit and concentration math done for you.
Binds alpha-2-delta subunit of voltage-gated calcium channels with higher affinity than gabapentin. Reduces excitatory neurotransmitter release. More predictable pharmacokinetics than gabapentin.
Controlled substance (CV). Sedation and ataxia at higher doses. More potent than gabapentin — lower doses needed. Taper to discontinue. Monitor for weight gain.
Species-specific contraindications and adverse-reaction reports for dogs may differ from canine / feline reference data — consult the primary citations listed with each rule.
Pregabalin dose range in dogs, with cited source references: PO 2–4 mg/kg q8-12h. Reference ranges from cited sources — verify against current literature before clinical use.
Documented routes for Pregabalin in dogs: PO.
Cited course lengths for Pregabalin in dogs include: Long-term; taper to discontinue. Duration depends on the indication — match it to the specific dose rule in the table above.
Pregabalin is indicated in dogs for: Neuropathic pain, seizures (adjunct).
These are general warnings for Pregabalin across species; consult the dog dosing table above for species-specific guidance. Controlled substance (CV). Sedation and ataxia at higher doses. More potent than gabapentin — lower doses needed. Taper to discontinue. Monitor for weight gain.
Why a species-specific page? Pregabalin pharmacokinetics differ across species: dose ranges, intervals, and route preferences are not interchangeable. Cross-extrapolation from canine doses is unsafe in dogs — the rules above are the citations specific to this species, not generic recommendations.
Sourced from published veterinary references; awaiting credentialed clinical reviewer. See our editorial process. Reference only — not veterinary advice.