ExoticRx · exoticrx.com/drugs/propofol-constant-rate-infusion
US brand names:PropoFlo CRI
Propofol Constant Rate Infusion is dosed at 0.1–0.4 mg/kg/min IV CRI after induction bolus (4-6mg/kg) in dogs, per Grimm KA, Lamont LA, Tranquilli WJ, Greene SA, Robertson SA. Veterinary Anesthesia and Analgesia: The Fifth Edition of Lumb and Jones. 5th ed. Wiley-Blackwell; 2015. — Verified against Plumb's Veterinary Drug Handbook, 10th Ed, p.1111 (2026-08-01).. Verify against current literature before clinical use.
GABA-A receptor agonist providing continuous plane of anesthesia without accumulation during prolonged procedures. Rapid onset and recovery.
Heinz body anemia in cats with repeated daily use (>3 days). Hypotension and apnea common. Strict aseptic technique — lipid emulsion supports bacterial growth.
Species references:All Cat (Domestic) drugsAll Dog (Domestic) drugs
Each ExoticRx dose rule is graded by the strength of its primary evidence — see the editorial process.
Propofol Constant Rate Infusion CRI dose rules from the ExoticRx formulary. Verify against current literature before clinical use; CRI rates differ from bolus dosing and route, dilution, and monitoring matter. Sign in for the complete per-species CRI protocol set.
| Species | Route | Rate | Indication | Evidence | Source |
|---|---|---|---|---|---|
| Dog (Domestic) | IV | 0.1–0.4 mg/kg/minCRI after induction bolus (4-6mg/kg) | Total IV anesthesia (TIVA) | Strong | Grimm KA, Lamont LA, Tranquilli WJ, Greene SA, Robertson SA. Veterinary Anesthesia and Analgesia: The Fifth Edition of Lumb and Jones. 5th ed. Wiley-Blackwell; 2015. — Verified against Plumb's Veterinary Drug Handbook, 10th Ed, p.1111 (2026-08-01). |
| Cat (Domestic) | IV | 0.1–0.3 mg/kg/minCRI after induction bolus (4-8mg/kg) | Total IV anesthesia/Short procedure maintenance | Strong | Campagna I, Schwarz A, Keller S, Bettschart-Wolfensberger R, Mosing M. Comparison of the effects of propofol or alfaxalone for anaesthesia induction and maintenance on respiration in cats. Vet Anaesth Analg. 2015;42(5):484-492. doi:10.1111/vaa.12231 — Verified against Plumb's Veterinary Drug Handbook, 10th Ed, p.1111 (2026-08-01). |
A dog/cat sample is shown here. Cited dosing for all 2 species — reptiles, birds, pocket pets, livestock, and equine — is free on the per-species pages above. Pro adds the weight-based calculator for every species.
| Species | Route | Dose | Frequency | Evidence | Source |
|---|---|---|---|---|---|
| Dog (Domestic) | IV | 0.1–0.4 mg/kg/min | CRI after induction bolus (4-6mg/kg) | Strong | Grimm KA, Lamont LA, Tranquilli WJ, Greene SA, Robertson SA. Veterinary Anesthesia and Analgesia: The Fifth Edition of Lumb and Jones. 5th ed. Wiley-Blackwell; 2015. — Verified against Plumb's Veterinary Drug Handbook, 10th Ed, p.1111 (2026-08-01). |
| Cat (Domestic) | IV | 0.1–0.3 mg/kg/min | CRI after induction bolus (4-8mg/kg) | Strong | Campagna I, Schwarz A, Keller S, Bettschart-Wolfensberger R, Mosing M. Comparison of the effects of propofol or alfaxalone for anaesthesia induction and maintenance on respiration in cats. Vet Anaesth Analg. 2015;42(5):484-492. doi:10.1111/vaa.12231 — Verified against Plumb's Veterinary Drug Handbook, 10th Ed, p.1111 (2026-08-01). |
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View PlansSource citations and evidence levels available on the live page. Reference only — verify against current literature before clinical use.
Total IV anesthesia (TIVA)
Total IV anesthesia/Short procedure maintenance