Dog · Canis lupus familiaris · typical adult weight 2.00–80.00 kg
Propofol Constant Rate Infusion is dosed at 0.1–0.4 mg/kg/min IV CRI after induction bolus (4-6mg/kg) in dogs, per Grimm KA, Lamont LA, Tranquilli WJ, Greene SA, Robertson SA. Veterinary Anesthesia and Analgesia: The Fifth Edition of Lumb and Jones. 5th ed. Wiley-Blackwell; 2015. — Verified against Plumb's Veterinary Drug Handbook, 10th Ed, p.1111 (2026-08-01). — Plumb's 10th ed (held) printed p.1080, Propofol monograph spanning p.1080-1085; page located 2026-08-05 from the book's own running heads, verified to name the drug in its body text. — SOURCE EDITION: Plumb's Veterinary Drug Handbook — ISBN 9781394172207, https://openlibrary.org/isbn/9781394172207. Propofol Constant Rate Infusion is used in dogs for Total IV anesthesia (TIVA). Routes documented in dogs: IV. A typical adult dog weighs 2.00–80.00 kg. ExoticRx lists 1 cited dose rule for Propofol Constant Rate Infusion in dogs, drawn from published veterinary references. Verify against current literature before clinical use.
US trade names: PropoFlo CRI
| Route | Dose | Frequency | Duration | Indication | Evidence | Source |
|---|---|---|---|---|---|---|
| IV | 0.1–0.4 mg/kg/min | CRI after induction bolus (4-6mg/kg) | Duration of procedure; rapid recovery after discontinuation | Total IV anesthesia (TIVA) | Strong | Grimm KA, Lamont LA, Tranquilli WJ, Greene SA, Robertson SA. Veterinary Anesthesia and Analgesia: The Fifth Edition of Lumb and Jones. 5th ed. Wiley-Blackwell; 2015. — Verified against Plumb's Veterinary Drug Handbook, 10th Ed, p.1111 (2026-08-01). — Plumb's 10th ed (held) printed p.1080, Propofol monograph spanning p.1080-1085; page located 2026-08-05 from the book's own running heads, verified to name the drug in its body text. — SOURCE EDITION: Plumb's Veterinary Drug Handbook — ISBN 9781394172207, https://openlibrary.org/isbn/9781394172207 |
Every held source for this drug and species, as printed. Where they differ, both are shown — the choice is yours, not ours.
The sources disagree for this combination. The ranges below do not overlap on a comparable route. This is not an error in one of them — published veterinary references differ, and reconciling them for a particular patient is a clinical judgement.
| Dose (%) | Route | Source | As printed |
|---|---|---|---|
| 30 | — | Papich Saunders Handbook of Veterinary Drugs, 4th edp.713 | premedications, lower the dose by 20%-30% (e.g., lower dose of 3 mg/kg can be |
| 20 | — | Papich Saunders Handbook of Veterinary Drugs, 4th edp.713 | premedications, lower the dose by 20%-30% (e.g., lower dose of 3 mg/kg can be |
| Dose (mcg/kg) | Route | Source | As printed |
|---|---|---|---|
| 100–400 |
One of the cited rules is a continuous-rate-infusion regimen: IV 0.1–0.4 mg/kg/min CRI after induction bolus (4-6mg/kg). CRI regimens are delivered as a continuous infusion rather than discrete doses — verify the rate against the cited source before use.
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These ranges are per kg. Enter your dog's weight to get the precise dose and draw-up volume — unit and concentration math done for you.
GABA-A receptor agonist providing continuous plane of anesthesia without accumulation during prolonged procedures. Rapid onset and recovery.
Heinz body anemia in cats with repeated daily use (>3 days). Hypotension and apnea common. Strict aseptic technique — lipid emulsion supports bacterial growth.
Species-specific contraindications and adverse-reaction reports for dogs may differ from canine / feline reference data — consult the primary citations listed with each rule.
Propofol Constant Rate Infusion dose range in dogs, with cited source references: IV 0.1–0.4 mg/kg/min CRI after induction bolus (4-6mg/kg). Reference ranges from cited sources — verify against current literature before clinical use.
Documented routes for Propofol Constant Rate Infusion in dogs: IV.
Cited course lengths for Propofol Constant Rate Infusion in dogs include: Duration of procedure; rapid recovery after discontinuation. Duration depends on the indication — match it to the specific dose rule in the table above.
Propofol Constant Rate Infusion is indicated in dogs for: Total IV anesthesia (TIVA).
These are general warnings for Propofol Constant Rate Infusion across species; consult the dog dosing table above for species-specific guidance. Heinz body anemia in cats with repeated daily use (>3 days). Hypotension and apnea common. Strict aseptic technique — lipid emulsion supports bacterial growth.
Why a species-specific page? Propofol Constant Rate Infusion pharmacokinetics differ across species: dose ranges, intervals, and route preferences are not interchangeable. Cross-extrapolation from canine doses is unsafe in dogs — the rules above are the citations specific to this species, not generic recommendations.
Sourced from published veterinary references; awaiting credentialed clinical reviewer. See our editorial process. Reference only — not veterinary advice.
| IV |
| Papich Saunders Handbook of Veterinary Drugs, 4th edp.713 |
| • CRI: 5 mg/kg slowly IV, followed by 100-400 mcg/kg/min (or 6-24 mg/kg/hour). |
| Dose (mg/kg) | Route | Source | As printed |
|---|---|---|---|
| 6–7 | IV | BSAVA Small Animal Formulary, 10th ed — Part A (Canine and Feline)p.363 | 6-7 mg/kg i.v.; premedicated 1-4 mg/kg i.v. Continuous rate infusion for sedation or maintenance of |
| 1–4 | IV | BSAVA Small Animal Formulary, 10th ed — Part A (Canine and Feline)p.363 | 6-7 mg/kg i.v.; premedicated 1-4 mg/kg i.v. Continuous rate infusion for sedation or maintenance of anaesthesia: 0.1-0.4 mg/kg/m |
| 3 | — | Papich Saunders Handbook of Veterinary Drugs, 4th edp.713 | premedications, lower the dose by 20%-30% (e.g., lower dose of 3 mg/kg can be |
| 1–3 | IV | Papich Saunders Handbook of Veterinary Drugs, 4th edp.713 | used). After initial induction, maintenance doses of 1-3 mg/kg IV can be used. |
| 5 | IV | Papich Saunders Handbook of Veterinary Drugs, 4th edp.713 | • CRI: 5 mg/kg slowly IV, followed by 100-400 mcg/kg/min (or 6-24 mg/kg/hour). |
| 6–24 | IV | Papich Saunders Handbook of Veterinary Drugs, 4th edp.713 | • CRI: 5 mg/kg slowly IV, followed by 100-400 mcg/kg/min (or 6-24 mg/kg/hour). |
| 1–6 | IV | Papich Saunders Handbook of Veterinary Drugs, 4th edp.713 | • Status epilepticus: 1-6 mg/kg IV (to effect), followed by CRI of 0.1-0.6 mg/ |
| 5–7 | IV | Papich Saunders Handbook of Veterinary Drugs, 4th edp.713 | duction is 5-7 mg/kg IV, most inductions can be performed with 3.7 (61.5) |
| 0.5–1 | — | Papich Saunders Handbook of Veterinary Drugs, 4th edp.713 | given at 0.5-1 mg/kg for intubation. Although the typical range needed for in- |
| 6.6 | IV | Papich Saunders Handbook of Veterinary Drugs, 4th edp.713 | • 6.6 mg/kg IV slowly over 30-60 seconds. If necessary, an additional dose can be |
Figures are transcribed from the cited page or table of each held edition and are shown for reference only. They are not dose recommendations, they do not feed the calculator, and none has been reviewed by a veterinarian.