ExoticRx · exoticrx.com/drugs/rabacfosadine
US brand names:Tanovea-CA1
Rabacfosadine is dosed at 1 mg/kg IV q3 weeks for 5 doses in dogs, per TANOVEA - Rabacfosadine Succinate Injection, Powder, for Solution [US Product Label for Dogs].; 2021. https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=5b36e345-fae9-40ea-a069-6fefba92a89f — Verified against Plumb's Veterinary Drug Handbook, 10th Ed, p.1135 (2026-08-01).. Verify against current literature before clinical use.
Prodrug that releases PMEG (a purine nucleotide analog) intracellularly, inhibiting DNA synthesis in rapidly dividing lymphoid cells.
Dogs only. Delayed pulmonary fibrosis (potentially fatal). Dermatologic toxicity. Monitor CBC. Conditionally approved for canine lymphoma.
Species references:All Dog (Domestic) drugs
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| Species | Route | Dose | Frequency | Evidence | Source |
|---|---|---|---|---|---|
| Dog (Domestic) | IV | 1 mg/kg | q3 weeks for 5 doses | Moderate | TANOVEA - Rabacfosadine Succinate Injection, Powder, for Solution [US Product Label for Dogs].; 2021. https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=5b36e345-fae9-40ea-a069-6fefba92a89f — Verified against Plumb's Veterinary Drug Handbook, 10th Ed, p.1135 (2026-08-01). |
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