Dog · Canis lupus familiaris · typical adult weight 2.00–80.00 kg
Sacubitril-Valsartan is dosed at 0.5–3 mg/kg PO q12h in dogs, per JVIM 2021; Veterinary Cardiology Literature. Sacubitril-Valsartan is used in dogs for Heart failure (ARNI therapy). Routes documented in dogs: PO. A typical adult dog weighs 2.00–80.00 kg. ExoticRx lists 1 cited dose rule for Sacubitril-Valsartan in dogs, drawn from published veterinary references. Verify against current literature before clinical use.
US trade names: Entresto
| Route | Dose | Frequency | Duration | Indication | Evidence | Source |
|---|---|---|---|---|---|---|
| PO | 0.5–3 mg/kg | q12h | Long-term; titrate over 2-4 weeks | Heart failure (ARNI therapy) | Weak | JVIM 2021; Veterinary Cardiology Literature |
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These ranges are per kg. Enter your dog's weight to get the precise dose and draw-up volume — unit and concentration math done for you.
Combines neprilysin inhibitor (sacubitril) with ARB (valsartan). Neprilysin inhibition increases natriuretic peptides promoting vasodilation and diuresis, while ARB blocks RAAS.
Do not combine with ACE inhibitors (angioedema risk). Monitor blood pressure and renal function. Emerging canine heart failure research.
Species-specific contraindications and adverse-reaction reports for dogs may differ from canine / feline reference data — consult the primary citations listed with each rule.
Sacubitril-Valsartan dose range in dogs, with cited source references: PO 0.5–3 mg/kg q12h. Reference ranges from cited sources — verify against current literature before clinical use.
Documented routes for Sacubitril-Valsartan in dogs: PO.
Cited course lengths for Sacubitril-Valsartan in dogs include: Long-term; titrate over 2-4 weeks. Duration depends on the indication — match it to the specific dose rule in the table above.
Sacubitril-Valsartan is indicated in dogs for: Heart failure (ARNI therapy).
These are general warnings for Sacubitril-Valsartan across species; consult the dog dosing table above for species-specific guidance. Do not combine with ACE inhibitors (angioedema risk). Monitor blood pressure and renal function. Emerging canine heart failure research.
Why a species-specific page? Sacubitril-Valsartan pharmacokinetics differ across species: dose ranges, intervals, and route preferences are not interchangeable. Cross-extrapolation from canine doses is unsafe in dogs — the rules above are the citations specific to this species, not generic recommendations.
Sourced from published veterinary references; awaiting credentialed clinical reviewer. See our editorial process. Reference only — not veterinary advice.