Cat · Felis catus · typical adult weight 2.50–7.00 kg
Spinosad is dosed at 50–75 mg/kg PO q30d in cats, per COMFORTIS - Spinosad Tablet, Chewable [US Product Label for Dogs and Cats]. Elanco US Inc.; 2018. https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=d3489ebc-9900-4377-9a8b-98ae7c38ebd2 — Verified against Plumb's Veterinary Drug Handbook, 10th Ed, p.1201 (2026-08-01). — Plumb's 10th ed (held) printed p.1173, Spinosad monograph spanning p.1173-1174; page located 2026-08-05 from the book's own running heads, verified to name the drug in its body text. — SOURCE EDITION: Plumb's Veterinary Drug Handbook — ISBN 9781394172207, https://openlibrary.org/isbn/9781394172207. Spinosad is used in cats for Flea control. Routes documented in cats: PO. A typical adult cat weighs 2.50–7.00 kg. ExoticRx lists 1 cited dose rule for Spinosad in cats, drawn from published veterinary references. Verify against current literature before clinical use.
US trade names: Comfortis
| Route | Dose | Frequency | Duration | Indication | Evidence | Source |
|---|---|---|---|---|---|---|
| PO | 50–75 mg/kg | q30d | Monthly oral | Flea control | Moderate | COMFORTIS - Spinosad Tablet, Chewable [US Product Label for Dogs and Cats]. Elanco US Inc.; 2018. https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=d3489ebc-9900-4377-9a8b-98ae7c38ebd2 — Verified against Plumb's Veterinary Drug Handbook, 10th Ed, p.1201 (2026-08-01). — Plumb's 10th ed (held) printed p.1173, Spinosad monograph spanning p.1173-1174; page located 2026-08-05 from the book's own running heads, verified to name the drug in its body text. — SOURCE EDITION: Plumb's Veterinary Drug Handbook — ISBN 9781394172207, https://openlibrary.org/isbn/9781394172207 |
Every held source for this drug and species, as printed. Where they differ, both are shown — the choice is yours, not ours.
| Dose (mg/kg) | Route | Source | As printed |
|---|---|---|---|
| 50–75 | PO | BSAVA Small Animal Formulary, 10th ed — Part A (Canine and Feline)p.401 | 50-75 mg/kg p.o. q28d with or immediately after food. Spiramycin see Metronidazole Spironolactone |
| 50–100 | PO | Papich Saunders Handbook of Veterinary Drugs, 4th edp.766 | • 50-100 mg/kg PO once per month. (The approved dose in some countries for |
| 50 | — | Papich Saunders Handbook of Veterinary Drugs, 4th edp.766 | cats is 50 mg/kg once per month.) |
Figures are transcribed from the cited page or table of each held edition and are shown for reference only. They are not dose recommendations, they do not feed the calculator, and none has been reviewed by a veterinarian.
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Activates insect nicotinic acetylcholine receptors at a unique site, causing involuntary muscle contractions, paralysis, and death of fleas.
Dogs and cats. Vomiting is the most common adverse effect. Do NOT use concurrently with high-dose ivermectin (increased neurotoxicity risk). Give with food.
Species-specific contraindications and adverse-reaction reports for cats may differ from canine / feline reference data — consult the primary citations listed with each rule.
Spinosad dose range in cats, with cited source references: PO 50–75 mg/kg q30d. Reference ranges from cited sources — verify against current literature before clinical use.
Documented routes for Spinosad in cats: PO.
Cited course lengths for Spinosad in cats include: Monthly oral. Duration depends on the indication — match it to the specific dose rule in the table above.
Spinosad is indicated in cats for: Flea control.
These are general warnings for Spinosad across species; consult the cat dosing table above for species-specific guidance. Dogs and cats. Vomiting is the most common adverse effect. Do NOT use concurrently with high-dose ivermectin (increased neurotoxicity risk). Give with food.
Why a species-specific page? Spinosad pharmacokinetics differ across species: dose ranges, intervals, and route preferences are not interchangeable. Cross-extrapolation from canine doses is unsafe in cats — the rules above are the citations specific to this species, not generic recommendations.
Sourced from published veterinary references; awaiting credentialed clinical reviewer. See our editorial process. Reference only — not veterinary advice.