Cat · Felis catus · typical adult weight 2.50–7.00 kg
Spinosad is dosed at 50–75 mg/kg PO q30d in cats, per COMFORTIS - Spinosad Tablet, Chewable [US Product Label for Dogs and Cats]. Elanco US Inc.; 2018. https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=d3489ebc-9900-4377-9a8b-98ae7c38ebd2 — Verified against Plumb's Veterinary Drug Handbook, 10th Ed, p.1201 (2026-08-01).. Spinosad is used in cats for Flea control. Routes documented in cats: PO. A typical adult cat weighs 2.50–7.00 kg. ExoticRx lists 1 cited dose rule for Spinosad in cats, drawn from published veterinary references. Verify against current literature before clinical use.
US trade names: Comfortis
| Route | Dose | Frequency | Duration | Indication | Evidence | Source |
|---|---|---|---|---|---|---|
| PO | 50–75 mg/kg | q30d | Monthly oral | Flea control | Moderate | COMFORTIS - Spinosad Tablet, Chewable [US Product Label for Dogs and Cats]. Elanco US Inc.; 2018. https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=d3489ebc-9900-4377-9a8b-98ae7c38ebd2 — Verified against Plumb's Veterinary Drug Handbook, 10th Ed, p.1201 (2026-08-01). |
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These ranges are per kg. Enter your cat's weight to get the precise dose and draw-up volume — unit and concentration math done for you.
Activates insect nicotinic acetylcholine receptors at a unique site, causing involuntary muscle contractions, paralysis, and death of fleas.
Dogs and cats. Vomiting is the most common adverse effect. Do NOT use concurrently with high-dose ivermectin (increased neurotoxicity risk). Give with food.
Species-specific contraindications and adverse-reaction reports for cats may differ from canine / feline reference data — consult the primary citations listed with each rule.
Spinosad dose range in cats, with cited source references: PO 50–75 mg/kg q30d. Reference ranges from cited sources — verify against current literature before clinical use.
Documented routes for Spinosad in cats: PO.
Cited course lengths for Spinosad in cats include: Monthly oral. Duration depends on the indication — match it to the specific dose rule in the table above.
Spinosad is indicated in cats for: Flea control.
These are general warnings for Spinosad across species; consult the cat dosing table above for species-specific guidance. Dogs and cats. Vomiting is the most common adverse effect. Do NOT use concurrently with high-dose ivermectin (increased neurotoxicity risk). Give with food.
Why a species-specific page? Spinosad pharmacokinetics differ across species: dose ranges, intervals, and route preferences are not interchangeable. Cross-extrapolation from canine doses is unsafe in cats — the rules above are the citations specific to this species, not generic recommendations.
Sourced from published veterinary references; awaiting credentialed clinical reviewer. See our editorial process. Reference only — not veterinary advice.