Spinosad for Cat
Cat · Felis catus · typical adult weight 2.50–7.00 kg
Spinosad is used in cat for Flea control. Routes documented in cat: PO. A typical adult cat weighs 2.50–7.00 kg. ExoticRx lists 1 cited dose rule for Spinosad in cat, drawn from published veterinary references. Verify against current literature before clinical use.
Trade names: Comfortis
Dose ranges
| Route | Dose | Frequency | Duration | Indication | Evidence | Source |
|---|---|---|---|---|---|---|
| PO | 50–75 mg/kg | q30d | Monthly oral | Flea control | Moderate | Plumb's Veterinary Drug Handbook, 9th Ed |
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These ranges are per kg. Enter your cat's weight to get the precise dose and draw-up volume — unit and concentration math done for you.
Mechanism of action
Activates insect nicotinic acetylcholine receptors at a unique site, causing involuntary muscle contractions, paralysis, and death of fleas.
Side effects & warnings
Dogs and cats. Vomiting is the most common adverse effect. Do NOT use concurrently with high-dose ivermectin (increased neurotoxicity risk). Give with food.
Species-specific contraindications and adverse-reaction reports for cat may differ from canine / feline reference data — consult the primary citations listed with each rule.
Other Antiparasitic drugs with cat dosing
Spinosad dosing in other species
Why a species-specific page? Spinosad pharmacokinetics differ across species: dose ranges, intervals, and route preferences are not interchangeable. Cross-extrapolation from canine doses is unsafe in cat — the rules above are the citations specific to this species, not generic recommendations.
Sourced from published veterinary references; awaiting credentialed clinical reviewer. See our editorial process. Reference only — not veterinary advice.