Dog · Canis lupus familiaris · typical adult weight 2.00–80.00 kg
Spinosad is dosed at 30–60 mg/kg PO q30d in dogs, per COMFORTIS - Spinosad Tablet, Chewable [US Product Label for Dogs and Cats]. Elanco US Inc.; 2018. https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=d3489ebc-9900-4377-9a8b-98ae7c38ebd2 — Verified against Plumb's Veterinary Drug Handbook, 10th Ed, p.1201 (2026-08-01). — Plumb's 10th ed (held) printed p.1173, Spinosad monograph spanning p.1173-1174; page located 2026-08-05 from the book's own running heads, verified to name the drug in its body text. — SOURCE EDITION: Plumb's Veterinary Drug Handbook — ISBN 9781394172207, https://openlibrary.org/isbn/9781394172207. Spinosad is used in dogs for Flea control. Routes documented in dogs: PO. A typical adult dog weighs 2.00–80.00 kg. ExoticRx lists 1 cited dose rule for Spinosad in dogs, drawn from published veterinary references. Verify against current literature before clinical use.
US trade names: Comfortis
| Route | Dose | Frequency | Duration | Indication | Evidence | Source |
|---|---|---|---|---|---|---|
| PO | 30–60 mg/kg | q30d | Monthly oral | Flea control | Strong | COMFORTIS - Spinosad Tablet, Chewable [US Product Label for Dogs and Cats]. Elanco US Inc.; 2018. https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=d3489ebc-9900-4377-9a8b-98ae7c38ebd2 — Verified against Plumb's Veterinary Drug Handbook, 10th Ed, p.1201 (2026-08-01). — Plumb's 10th ed (held) printed p.1173, Spinosad monograph spanning p.1173-1174; page located 2026-08-05 from the book's own running heads, verified to name the drug in its body text. — SOURCE EDITION: Plumb's Veterinary Drug Handbook — ISBN 9781394172207, https://openlibrary.org/isbn/9781394172207 |
Every held source for this drug and species, as printed. Where they differ, both are shown — the choice is yours, not ours.
The sources disagree for this combination. The ranges below do not overlap on a comparable route. This is not an error in one of them — published veterinary references differ, and reconciling them for a particular patient is a clinical judgement.
| Dose (mg/kg) | Route | Source | As printed |
|---|---|---|---|
| 45–70 | PO | BSAVA Small Animal Formulary, 10th ed — Part A (Canine and Feline)p.401 | 45-70 mg/kg p.o. q28d with or immediately after food |
| 30 | PO | Papich Saunders Handbook of Veterinary Drugs, 4th edp.766 | • 30 mg/kg (13.5 mg/lb) PO administered once per month. |
| Dose (mg/lb) | Route | Source | As printed |
|---|---|---|---|
| 13.5 |
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Activates insect nicotinic acetylcholine receptors at a unique site, causing involuntary muscle contractions, paralysis, and death of fleas.
Dogs and cats. Vomiting is the most common adverse effect. Do NOT use concurrently with high-dose ivermectin (increased neurotoxicity risk). Give with food.
Species-specific contraindications and adverse-reaction reports for dogs may differ from canine / feline reference data — consult the primary citations listed with each rule.
Spinosad dose range in dogs, with cited source references: PO 30–60 mg/kg q30d. Reference ranges from cited sources — verify against current literature before clinical use.
Documented routes for Spinosad in dogs: PO.
Cited course lengths for Spinosad in dogs include: Monthly oral. Duration depends on the indication — match it to the specific dose rule in the table above.
Spinosad is indicated in dogs for: Flea control.
These are general warnings for Spinosad across species; consult the dog dosing table above for species-specific guidance. Dogs and cats. Vomiting is the most common adverse effect. Do NOT use concurrently with high-dose ivermectin (increased neurotoxicity risk). Give with food.
Why a species-specific page? Spinosad pharmacokinetics differ across species: dose ranges, intervals, and route preferences are not interchangeable. Cross-extrapolation from canine doses is unsafe in dogs — the rules above are the citations specific to this species, not generic recommendations.
Sourced from published veterinary references; awaiting credentialed clinical reviewer. See our editorial process. Reference only — not veterinary advice.
| PO |
| Papich Saunders Handbook of Veterinary Drugs, 4th edp.766 |
| • 30 mg/kg (13.5 mg/lb) PO administered once per month. |
Figures are transcribed from the cited page or table of each held edition and are shown for reference only. They are not dose recommendations, they do not feed the calculator, and none has been reviewed by a veterinarian.