Livestock · Bos taurus · typical adult weight 250.00–900.00 kg
Sulfamethazine is dosed at 110–220 mg/kg PO Loading dose then q24h in cattle, per Verified against Papich/Saunders Handbook of Veterinary Drugs, 4th Ed, p.781 (2026-08-01). — 21 CFR § 520.2261b (Sulfamethazine powder), conditions of use for Cattle: 119.05-119.05 mg/kg (the regulation prints this per pound; converted at 2.2046226 lb/kg). Related tolerances: 21 CFR § 556.670. Retrieved from the eCFR API, snapshot 2026-01-01. https://www.ecfr.gov/current/title-21/section-520.2261b — LOCATOR CONVENTION 2026-08-07: the bare 'p.781' in this citation is the PDF index of the held scan, not the printed page. The PRINTED page is p.753; verified by finding the drug named there. If you are holding the book, turn to p.753. — SOURCE EDITION: Saunders Handbook of Veterinary Drugs — ISBN 9780323244855, https://openlibrary.org/isbn/9780323244855. Sulfamethazine is used in cattle for Bacterial pneumonia, foot rot, coccidiosis. Routes documented in cattle: PO. A typical adult cattle weighs 250.00–900.00 kg. ExoticRx lists 1 cited dose rule for Sulfamethazine in cattle, drawn from published veterinary references. Verify against current literature before clinical use.
US trade names: Sulmet
| Route | Dose | Frequency | Duration | Indication | Evidence | Source |
|---|---|---|---|---|---|---|
| PO | 110–220 mg/kg | Loading dose then q24h | 220mg/kg day 1 then 110mg/kg x 4 days | Bacterial pneumonia, foot rot, coccidiosis | Strong | Verified against Papich/Saunders Handbook of Veterinary Drugs, 4th Ed, p.781 (2026-08-01). — 21 CFR § 520.2261b (Sulfamethazine powder), conditions of use for Cattle: 119.05-119.05 mg/kg (the regulation prints this per pound; converted at 2.2046226 lb/kg). Related tolerances: 21 CFR § 556.670. Retrieved from the eCFR API, snapshot 2026-01-01. https://www.ecfr.gov/current/title-21/section-520.2261b — LOCATOR CONVENTION 2026-08-07: the bare 'p.781' in this citation is the PDF index of the held scan, not the printed page. The PRINTED page is p.753; verified by finding the drug named there. If you are holding the book, turn to p.753. — SOURCE EDITION: Saunders Handbook of Veterinary Drugs — ISBN 9780323244855, https://openlibrary.org/isbn/9780323244855 |
Every held source for this drug and species, as printed. Where they differ, both are shown — the choice is yours, not ours.
| Dose (mg/kg) | Route | Source | As printed |
|---|---|---|---|
| 220 | — | Papich Saunders Handbook of Veterinary Drugs, 4th edp.781 | • Treatment of pneumonia and other infections: 220 mg/kg as initial dose, followed |
| 110 | PO | Papich Saunders Handbook of Veterinary Drugs, 4th edp.781 | by 110 mg/kg q24h PO. |
| 237 | — | Papich Saunders Handbook of Veterinary Drugs, 4th edp.781 | • Use of soluble powder as a drench or in drinking water: 237 mg/kg as initial |
| 119 | PO | Papich Saunders Handbook of Veterinary Drugs, 4th edp.781 | dose, followed by 119 mg/kg q24h PO. |
Need the exact dose for your patient?
These ranges are per kg. Enter your cattle's weight to get the precise dose and draw-up volume — unit and concentration math done for you.
Inhibits dihydropteroate synthase in bacterial folate synthesis. Used primarily in food animals and poultry for coccidiosis.
Withdrawal times required in food animals. Crystalluria risk. Adequate water intake essential. May cause blood dyscrasias with prolonged use.
Species-specific contraindications and adverse-reaction reports for cattle may differ from canine / feline reference data — consult the primary citations listed with each rule.
Sulfamethazine dose range in cattle, with cited source references: PO 110–220 mg/kg Loading dose then q24h. Reference ranges from cited sources — verify against current literature before clinical use.
Documented routes for Sulfamethazine in cattle: PO.
Cited course lengths for Sulfamethazine in cattle include: 220mg/kg day 1 then 110mg/kg x 4 days. Duration depends on the indication — match it to the specific dose rule in the table above.
Sulfamethazine is indicated in cattle for: Bacterial pneumonia, foot rot, coccidiosis.
These are general warnings for Sulfamethazine across species; consult the cattle dosing table above for species-specific guidance. Withdrawal times required in food animals. Crystalluria risk. Adequate water intake essential. May cause blood dyscrasias with prolonged use.
Why a species-specific page? Sulfamethazine pharmacokinetics differ across species: dose ranges, intervals, and route preferences are not interchangeable. Cross-extrapolation from canine doses is unsafe in cattle — the rules above are the citations specific to this species, not generic recommendations.
Sourced from published veterinary references; awaiting credentialed clinical reviewer. See our editorial process. Reference only — not veterinary advice.
| 350–400 |
| PO |
| Papich Saunders Handbook of Veterinary Drugs, 4th edp.781 |
| • Sustained-release bolus: 350-400 mg/kg PO as a single dose. |
Figures are transcribed from the cited page or table of each held edition and are shown for reference only. They are not dose recommendations, they do not feed the calculator, and none has been reviewed by a veterinarian.