Dog · Canis lupus familiaris · typical adult weight 2.00–80.00 kg
Warfarin is dosed at 0.05–0.2 mg/kg PO q24h in dogs, per Winter RL, Sedacca CD, Adams A, Orton EC. Aortic thrombosis in dogs: presentation, therapy, and outcome in 26 cases. J Vet Cardiol. 2012;14(2):333-342. doi:10.1016/j.jvc.2012.02.008; Smith SA. Antithrombotic therapy. Top Companion Anim Med. 2012;27(2):88-94.; Arai S, Callan MB. Warfarin therapy in a dog with acute arterial thrombosis and pyometra. Can Vet J. 2014;55(11):1066-1068.; Usechak PJ, Bright JM, Day TK. Thrombotic complications associated with atrial fibrillation in three dogs. J Vet Cardiol. 2012;14(3):453-458. doi:10.1016/j.jvc.2012.04.003 — Verified against Plumb's Veterinary Drug Handbook, 10th Ed, p.1345 (2026-08-01).. Warfarin is used in dogs for Thromboembolism prevention. Routes documented in dogs: PO. A typical adult dog weighs 2.00–80.00 kg. ExoticRx lists 1 cited dose rule for Warfarin in dogs, drawn from published veterinary references. Verify against current literature before clinical use.
US trade names: Coumadin, Jantoven
| Route | Dose | Frequency | Duration | Indication | Evidence | Source |
|---|---|---|---|---|---|---|
| PO | 0.05–0.2 mg/kg | q24h | Long-term; frequent PT/INR monitoring required (target INR 2.0-3.0) | Thromboembolism prevention | Moderate | Winter RL, Sedacca CD, Adams A, Orton EC. Aortic thrombosis in dogs: presentation, therapy, and outcome in 26 cases. J Vet Cardiol. 2012;14(2):333-342. doi:10.1016/j.jvc.2012.02.008; Smith SA. Antithrombotic therapy. Top Companion Anim Med. 2012;27(2):88-94.; Arai S, Callan MB. Warfarin therapy in a dog with acute arterial thrombosis and pyometra. Can Vet J. 2014;55(11):1066-1068.; Usechak PJ, Bright JM, Day TK. Thrombotic complications associated with atrial fibrillation in three dogs. J Vet Cardiol. 2012;14(3):453-458. doi:10.1016/j.jvc.2012.04.003 — Verified against Plumb's Veterinary Drug Handbook, 10th Ed, p.1345 (2026-08-01). |
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These ranges are per kg. Enter your dog's weight to get the precise dose and draw-up volume — unit and concentration math done for you.
Inhibits vitamin K epoxide reductase, blocking synthesis of vitamin K-dependent clotting factors (II, VII, IX, X).
Narrow therapeutic index. Frequent PT/INR monitoring required. Numerous drug and dietary interactions. Hemorrhage is the main risk.
Species-specific contraindications and adverse-reaction reports for dogs may differ from canine / feline reference data — consult the primary citations listed with each rule.
Warfarin dose range in dogs, with cited source references: PO 0.05–0.2 mg/kg q24h. Reference ranges from cited sources — verify against current literature before clinical use.
Documented routes for Warfarin in dogs: PO.
Cited course lengths for Warfarin in dogs include: Long-term; frequent PT/INR monitoring required (target INR 2.0-3.0). Duration depends on the indication — match it to the specific dose rule in the table above.
Warfarin is indicated in dogs for: Thromboembolism prevention.
These are general warnings for Warfarin across species; consult the dog dosing table above for species-specific guidance. Narrow therapeutic index. Frequent PT/INR monitoring required. Numerous drug and dietary interactions. Hemorrhage is the main risk.
Why a species-specific page? Warfarin pharmacokinetics differ across species: dose ranges, intervals, and route preferences are not interchangeable. Cross-extrapolation from canine doses is unsafe in dogs — the rules above are the citations specific to this species, not generic recommendations.
Sourced from published veterinary references; awaiting credentialed clinical reviewer. See our editorial process. Reference only — not veterinary advice.