Dog · Canis lupus familiaris · typical adult weight 2.00–80.00 kg
Warfarin is dosed at 0.05–0.2 mg/kg PO q24h in dogs, per Winter RL, Sedacca CD, Adams A, Orton EC. Aortic thrombosis in dogs: presentation, therapy, and outcome in 26 cases. J Vet Cardiol. 2012;14(2):333-342. doi:10.1016/j.jvc.2012.02.008; Smith SA. Antithrombotic therapy. Top Companion Anim Med. 2012;27(2):88-94.; Arai S, Callan MB. Warfarin therapy in a dog with acute arterial thrombosis and pyometra. Can Vet J. 2014;55(11):1066-1068.; Usechak PJ, Bright JM, Day TK. Thrombotic complications associated with atrial fibrillation in three dogs. J Vet Cardiol. 2012;14(3):453-458. doi:10.1016/j.jvc.2012.04.003 — Verified against Plumb's Veterinary Drug Handbook, 10th Ed, p.1345 (2026-08-01). — Plumb's 10th ed (held) printed p.1318, Warfarin monograph spanning p.1317-1318; page located 2026-08-05 from the book's own running heads, and carries this exact dose under the matching species heading. — SOURCE EDITION: Plumb's Veterinary Drug Handbook — ISBN 9781394172207, https://openlibrary.org/isbn/9781394172207. Warfarin is used in dogs for Thromboembolism prevention. Routes documented in dogs: PO. A typical adult dog weighs 2.00–80.00 kg. ExoticRx lists 1 cited dose rule for Warfarin in dogs, drawn from published veterinary references. Verify against current literature before clinical use.
US trade names: Coumadin, Jantoven
| Route | Dose | Frequency | Duration | Indication | Evidence | Source |
|---|---|---|---|---|---|---|
| PO | 0.05–0.2 mg/kg | q24h | Long-term; frequent PT/INR monitoring required (target INR 2.0-3.0) | Thromboembolism prevention | Moderate | Winter RL, Sedacca CD, Adams A, Orton EC. Aortic thrombosis in dogs: presentation, therapy, and outcome in 26 cases. J Vet Cardiol. 2012;14(2):333-342. doi:10.1016/j.jvc.2012.02.008; Smith SA. Antithrombotic therapy. Top Companion Anim Med. 2012;27(2):88-94.; Arai S, Callan MB. Warfarin therapy in a dog with acute arterial thrombosis and pyometra. Can Vet J. 2014;55(11):1066-1068.; Usechak PJ, Bright JM, Day TK. Thrombotic complications associated with atrial fibrillation in three dogs. J Vet Cardiol. 2012;14(3):453-458. doi:10.1016/j.jvc.2012.04.003 — Verified against Plumb's Veterinary Drug Handbook, 10th Ed, p.1345 (2026-08-01). — Plumb's 10th ed (held) printed p.1318, Warfarin monograph spanning p.1317-1318; page located 2026-08-05 from the book's own running heads, and carries this exact dose under the matching species heading. — SOURCE EDITION: Plumb's Veterinary Drug Handbook — ISBN 9781394172207, https://openlibrary.org/isbn/9781394172207 |
Every held source for this drug and species, as printed. Where they differ, both are shown — the choice is yours, not ours.
| Dose (mg/kg) | Route | Source | As printed |
|---|---|---|---|
| 0.1–0.2 | PO | Papich Saunders Handbook of Veterinary Drugs, 4th edp.877 | • 0.1-0.2 mg/kg q24h PO. Start with this dose q12h for the first 2-4 days because |
Figures are transcribed from the cited page or table of each held edition and are shown for reference only. They are not dose recommendations, they do not feed the calculator, and none has been reviewed by a veterinarian.
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These ranges are per kg. Enter your dog's weight to get the precise dose and draw-up volume — unit and concentration math done for you.
Inhibits vitamin K epoxide reductase, blocking synthesis of vitamin K-dependent clotting factors (II, VII, IX, X).
Narrow therapeutic index. Frequent PT/INR monitoring required. Numerous drug and dietary interactions. Hemorrhage is the main risk.
Species-specific contraindications and adverse-reaction reports for dogs may differ from canine / feline reference data — consult the primary citations listed with each rule.
Warfarin dose range in dogs, with cited source references: PO 0.05–0.2 mg/kg q24h. Reference ranges from cited sources — verify against current literature before clinical use.
Documented routes for Warfarin in dogs: PO.
Cited course lengths for Warfarin in dogs include: Long-term; frequent PT/INR monitoring required (target INR 2.0-3.0). Duration depends on the indication — match it to the specific dose rule in the table above.
Warfarin is indicated in dogs for: Thromboembolism prevention.
These are general warnings for Warfarin across species; consult the dog dosing table above for species-specific guidance. Narrow therapeutic index. Frequent PT/INR monitoring required. Numerous drug and dietary interactions. Hemorrhage is the main risk.
Why a species-specific page? Warfarin pharmacokinetics differ across species: dose ranges, intervals, and route preferences are not interchangeable. Cross-extrapolation from canine doses is unsafe in dogs — the rules above are the citations specific to this species, not generic recommendations.
Sourced from published veterinary references; awaiting credentialed clinical reviewer. See our editorial process. Reference only — not veterinary advice.