Zafirlukast for Dog
Dog · Canis lupus familiaris · typical adult weight 2.00–80.00 kg
Zafirlukast is used in dog for Airway inflammation (investigational). Routes documented in dog: PO. A typical adult dog weighs 2.00–80.00 kg. ExoticRx lists 1 cited dose rule for Zafirlukast in dog, drawn from published veterinary references. Verify against current literature before clinical use.
Trade names: Accolate
Dose ranges
| Route | Dose | Frequency | Duration | Indication | Evidence | Source |
|---|---|---|---|---|---|---|
| PO | 1–5 mg/kg | q12h | Long-term | Airway inflammation (investigational) | Weak | Plumb's Veterinary Drug Handbook, 9th Ed |
Need the exact dose for your patient?
These ranges are per kg. Enter your dog's weight to get the precise dose and draw-up volume — unit and concentration math done for you.
Mechanism of action
Competitive CysLT1 receptor antagonist blocking leukotriene D4 and E4 effects. Reduces bronchoconstriction and airway inflammation.
Side effects & warnings
Give on empty stomach (food reduces absorption by 40%). Hepatotoxicity rare but monitor liver enzymes. CYP2C9 inhibitor — drug interactions. Limited vet data.
Species-specific contraindications and adverse-reaction reports for dog may differ from canine / feline reference data — consult the primary citations listed with each rule.
Other Respiratory drugs with dog dosing
Why a species-specific page? Zafirlukast pharmacokinetics differ across species: dose ranges, intervals, and route preferences are not interchangeable. Cross-extrapolation from canine doses is unsafe in dog — the rules above are the citations specific to this species, not generic recommendations.
Sourced from published veterinary references; awaiting credentialed clinical reviewer. See our editorial process. Reference only — not veterinary advice.