Dog · Canis lupus familiaris · typical adult weight 2.00–80.00 kg
Ezogabine is used in dog for Refractory epilepsy (investigational). Routes documented in dog: PO. A typical adult dog weighs 2.00–80.00 kg. ExoticRx lists 1 cited dose rule for Ezogabine in dog, drawn from published veterinary references. Verify against current literature before clinical use.
Trade names: Potiga
| Route | Dose | Frequency | Duration | Indication | Evidence | Source |
|---|---|---|---|---|---|---|
| PO | 2–5 mg/kg | q8h | Investigational; no established veterinary protocol | Refractory epilepsy (investigational) | Anecdotal | Plumb's Veterinary Drug Handbook, 9th Ed |
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These ranges are per kg. Enter your dog's weight to get the precise dose and draw-up volume — unit and concentration math done for you.
First potassium channel opener anticonvulsant. Activates KCNQ2/3 (Kv7.2/7.3) potassium channels, stabilizing resting membrane potential and reducing neuronal excitability.
Retinal pigment changes and skin discoloration with chronic use. Urinary retention. Withdrawn from human market but available for veterinary investigational use. Limited data.
Species-specific contraindications and adverse-reaction reports for dog may differ from canine / feline reference data — consult the primary citations listed with each rule.
Why a species-specific page? Ezogabine pharmacokinetics differ across species: dose ranges, intervals, and route preferences are not interchangeable. Cross-extrapolation from canine doses is unsafe in dog — the rules above are the citations specific to this species, not generic recommendations.
Sourced from published veterinary references; awaiting credentialed clinical reviewer. See our editorial process. Reference only — not veterinary advice.