Dog · Canis lupus familiaris · typical adult weight 2.00–80.00 kg
Hydralazine is dosed at 0.5–2 mg/kg PO q12h in dogs, per Verified against Plumb's Veterinary Drug Handbook, 10th Ed, p.635 (2026-08-01). — Plumb's 10th ed (held) printed p.607, Hydralazine monograph spanning p.607-609; page located 2026-08-05 from the book's own running heads, verified to name the drug in its body text. — SOURCE EDITION: Plumb's Veterinary Drug Handbook — ISBN 9781394172207, https://openlibrary.org/isbn/9781394172207. Hydralazine is used in dogs for Acute mitral regurgitation, afterload reduction. Routes documented in dogs: PO. A typical adult dog weighs 2.00–80.00 kg. ExoticRx lists 1 cited dose rule for Hydralazine in dogs, drawn from published veterinary references. Verify against current literature before clinical use.
US trade names: Apresoline
| Route | Dose | Frequency | Duration | Indication | Evidence | Source |
|---|---|---|---|---|---|---|
| PO | 0.5–2 mg/kg | q12h | Until stabilized | Acute mitral regurgitation, afterload reduction | Moderate | Verified against Plumb's Veterinary Drug Handbook, 10th Ed, p.635 (2026-08-01). — Plumb's 10th ed (held) printed p.607, Hydralazine monograph spanning p.607-609; page located 2026-08-05 from the book's own running heads, verified to name the drug in its body text. — SOURCE EDITION: Plumb's Veterinary Drug Handbook — ISBN 9781394172207, https://openlibrary.org/isbn/9781394172207 |
Every held source for this drug and species, as printed. Where they differ, both are shown — the choice is yours, not ours.
The sources disagree for this combination. The ranges below do not overlap on a comparable route. This is not an error in one of them — published veterinary references differ, and reconciling them for a particular patient is a clinical judgement.
| Dose (mg/kg) | Route | Source | As printed |
|---|---|---|---|
| 0.5–3 | PO | BSAVA Small Animal Formulary, 10th ed — Part A (Canine and Feline)p.211 | 0.5-3 mg/kg p.o. q8-12h. Start at low dose (0.5-1 mg/kg q12h), monitor blood pressure regularly and i |
| 0.5–1 | — | BSAVA Small Animal Formulary, 10th ed — Part A (Canine and Feline)p.211 | 0.5-3 mg/kg p.o. q8-12h. Start at low dose (0.5-1 mg/kg q12h), monitor blood pressure regularly and increase to 2 mg/kg or even 3 mg/kg q12h if n |
| 2 | — | BSAVA Small Animal Formulary, 10th ed — Part A (Canine and Feline)p.211 | /kg q12h), monitor blood pressure regularly and increase to 2 mg/kg or even 3 mg/kg q12h if necessary |
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Directly relaxes arteriolar smooth muscle via interference with calcium transport, reducing afterload.
Reflex tachycardia common (often used with beta-blocker). Hypotension. Monitor blood pressure. Used for acute mitral regurgitation and aortic insufficiency.
Species-specific contraindications and adverse-reaction reports for dogs may differ from canine / feline reference data — consult the primary citations listed with each rule.
Hydralazine dose range in dogs, with cited source references: PO 0.5–2 mg/kg q12h. Reference ranges from cited sources — verify against current literature before clinical use.
Documented routes for Hydralazine in dogs: PO.
Cited course lengths for Hydralazine in dogs include: Until stabilized. Duration depends on the indication — match it to the specific dose rule in the table above.
Hydralazine is indicated in dogs for: Acute mitral regurgitation, afterload reduction.
These are general warnings for Hydralazine across species; consult the dog dosing table above for species-specific guidance. Reflex tachycardia common (often used with beta-blocker). Hypotension. Monitor blood pressure. Used for acute mitral regurgitation and aortic insufficiency.
Why a species-specific page? Hydralazine pharmacokinetics differ across species: dose ranges, intervals, and route preferences are not interchangeable. Cross-extrapolation from canine doses is unsafe in dogs — the rules above are the citations specific to this species, not generic recommendations.
Sourced from published veterinary references; awaiting credentialed clinical reviewer. See our editorial process. Reference only — not veterinary advice.
| 3 | — | BSAVA Small Animal Formulary, 10th ed — Part A (Canine and Feline)p.211 | or blood pressure regularly and increase to 2 mg/kg or even 3 mg/kg q12h if necessary |
| 0.5 | PO | Papich Saunders Handbook of Veterinary Drugs, 4th edp.405 | • 0.5 mg/kg (initial dose); titrate to 0.5-2 mg/kg q12h PO. |
| 0.5–2 | PO | Papich Saunders Handbook of Veterinary Drugs, 4th edp.405 | • 0.5 mg/kg (initial dose); titrate to 0.5-2 mg/kg q12h PO. |
Figures are transcribed from the cited page or table of each held edition and are shown for reference only. They are not dose recommendations, they do not feed the calculator, and none has been reviewed by a veterinarian.