Dog · Canis lupus familiaris · typical adult weight 2.00–80.00 kg
Isosorbide Dinitrate is dosed at 0.5–2 mg/kg PO q8-12h in dogs, per Plumb's Veterinary Drug Handbook, 9th Ed. Isosorbide Dinitrate is used in dogs for Congestive heart failure (preload reduction). Routes documented in dogs: PO. A typical adult dog weighs 2.00–80.00 kg. ExoticRx lists 1 cited dose rule for Isosorbide Dinitrate in dogs, drawn from published veterinary references. Verify against current literature before clinical use.
US trade names: Isordil, Dilatrate
| Route | Dose | Frequency | Duration | Indication | Evidence | Source |
|---|---|---|---|---|---|---|
| PO | 0.5–2 mg/kg | q8-12h | Long-term; provide nitrate-free interval of 10-12h daily | Congestive heart failure (preload reduction) | Weak | Plumb's Veterinary Drug Handbook, 9th Ed |
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These ranges are per kg. Enter your dog's weight to get the precise dose and draw-up volume — unit and concentration math done for you.
Organic nitrate that releases nitric oxide, causing venodilation primarily and some arteriolar dilation, reducing preload and myocardial oxygen demand.
Tolerance develops with continuous use — nitrate-free interval recommended. Hypotension risk. Headache common.
Species-specific contraindications and adverse-reaction reports for dogs may differ from canine / feline reference data — consult the primary citations listed with each rule.
Isosorbide Dinitrate dose range in dogs, with cited source references: PO 0.5–2 mg/kg q8-12h. Reference ranges from cited sources — verify against current literature before clinical use.
Documented routes for Isosorbide Dinitrate in dogs: PO.
Cited course lengths for Isosorbide Dinitrate in dogs include: Long-term; provide nitrate-free interval of 10-12h daily. Duration depends on the indication — match it to the specific dose rule in the table above.
Isosorbide Dinitrate is indicated in dogs for: Congestive heart failure (preload reduction).
These are general warnings for Isosorbide Dinitrate across species; consult the dog dosing table above for species-specific guidance. Tolerance develops with continuous use — nitrate-free interval recommended. Hypotension risk. Headache common.
Why a species-specific page? Isosorbide Dinitrate pharmacokinetics differ across species: dose ranges, intervals, and route preferences are not interchangeable. Cross-extrapolation from canine doses is unsafe in dogs — the rules above are the citations specific to this species, not generic recommendations.
Sourced from published veterinary references; awaiting credentialed clinical reviewer. See our editorial process. Reference only — not veterinary advice.