ExoticRx · exoticrx.com/drugs/l-asparaginase
US brand names:Elspar, Kidrolase
L-Asparaginase is dosed at 400 IU/kg IM once per protocol cycle in dogs, per Verified against Plumb's Veterinary Drug Handbook, 10th Ed, p.126 (2026-08-01).. Verify against current literature before clinical use.
Enzyme that depletes extracellular asparagine. Tumor cells (especially lymphoblasts) lack asparagine synthetase and die from asparagine depletion.
Anaphylaxis risk (especially with repeated use). Pre-treat with antihistamine. Pancreatitis risk. Coagulopathy (reduces clotting factors). IM preferred to reduce anaphylaxis risk.
Species references:All Dog (Domestic) drugs
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A dog/cat sample is shown here. Cited dosing for all 1 species — reptiles, birds, pocket pets, livestock, and equine — is free on the per-species pages above. Pro adds the weight-based calculator for every species.
| Species | Route | Dose | Frequency | Evidence | Source |
|---|---|---|---|---|---|
| Dog (Domestic) | IM | 400 IU/kg | once per protocol cycle | Strong | Verified against Plumb's Veterinary Drug Handbook, 10th Ed, p.126 (2026-08-01). |
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View PlansSource citations and evidence levels available on the live page. Reference only — verify against current literature before clinical use.