Dog · Canis lupus familiaris · typical adult weight 2.00–80.00 kg
L-Asparaginase is dosed at 400 IU/kg IM once per protocol cycle in dogs, per Verified against Plumb's Veterinary Drug Handbook, 10th Ed, p.126 (2026-08-01).. L-Asparaginase is used in dogs for Lymphoma (induction). Routes documented in dogs: IM. A typical adult dog weighs 2.00–80.00 kg. ExoticRx lists 1 cited dose rule for L-Asparaginase in dogs, drawn from published veterinary references. Verify against current literature before clinical use.
US trade names: Elspar, Kidrolase
| Route | Dose | Frequency | Duration | Indication | Evidence | Source |
|---|---|---|---|---|---|---|
| IM | 400 IU/kg | once per protocol cycle | Usually 1-2 doses total | Lymphoma (induction) | Strong | Verified against Plumb's Veterinary Drug Handbook, 10th Ed, p.126 (2026-08-01). |
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Enzyme that depletes extracellular asparagine. Tumor cells (especially lymphoblasts) lack asparagine synthetase and die from asparagine depletion.
Anaphylaxis risk (especially with repeated use). Pre-treat with antihistamine. Pancreatitis risk. Coagulopathy (reduces clotting factors). IM preferred to reduce anaphylaxis risk.
Species-specific contraindications and adverse-reaction reports for dogs may differ from canine / feline reference data — consult the primary citations listed with each rule.
L-Asparaginase dose range in dogs, with cited source references: IM 400 IU/kg once per protocol cycle. Reference ranges from cited sources — verify against current literature before clinical use.
Documented routes for L-Asparaginase in dogs: IM.
Cited course lengths for L-Asparaginase in dogs include: Usually 1-2 doses total. Duration depends on the indication — match it to the specific dose rule in the table above.
L-Asparaginase is indicated in dogs for: Lymphoma (induction).
These are general warnings for L-Asparaginase across species; consult the dog dosing table above for species-specific guidance. Anaphylaxis risk (especially with repeated use). Pre-treat with antihistamine. Pancreatitis risk. Coagulopathy (reduces clotting factors). IM preferred to reduce anaphylaxis risk.
Why a species-specific page? L-Asparaginase pharmacokinetics differ across species: dose ranges, intervals, and route preferences are not interchangeable. Cross-extrapolation from canine doses is unsafe in dogs — the rules above are the citations specific to this species, not generic recommendations.
Sourced from published veterinary references; awaiting credentialed clinical reviewer. See our editorial process. Reference only — not veterinary advice.