Dog · Canis lupus familiaris · typical adult weight 2.00–80.00 kg
L-Asparaginase is used in dog for Lymphoma (induction). Routes documented in dog: IM. A typical adult dog weighs 2.00–80.00 kg. ExoticRx lists 1 cited dose rule for L-Asparaginase in dog, drawn from published veterinary references. Verify against current literature before clinical use.
Trade names: Elspar, Kidrolase
| Route | Dose | Frequency | Duration | Indication | Evidence | Source |
|---|---|---|---|---|---|---|
| IM | 400 IU/kg | once per protocol cycle | Usually 1-2 doses total | Lymphoma (induction) | Strong | Plumb's Veterinary Drug Handbook, 9th Ed |
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These ranges are per kg. Enter your dog's weight to get the precise dose and draw-up volume — unit and concentration math done for you.
Enzyme that depletes extracellular asparagine. Tumor cells (especially lymphoblasts) lack asparagine synthetase and die from asparagine depletion.
Anaphylaxis risk (especially with repeated use). Pre-treat with antihistamine. Pancreatitis risk. Coagulopathy (reduces clotting factors). IM preferred to reduce anaphylaxis risk.
Species-specific contraindications and adverse-reaction reports for dog may differ from canine / feline reference data — consult the primary citations listed with each rule.
Why a species-specific page? L-Asparaginase pharmacokinetics differ across species: dose ranges, intervals, and route preferences are not interchangeable. Cross-extrapolation from canine doses is unsafe in dog — the rules above are the citations specific to this species, not generic recommendations.
Sourced from published veterinary references; awaiting credentialed clinical reviewer. See our editorial process. Reference only — not veterinary advice.