ExoticRx · exoticrx.com/drugs/lomustine
US brand names:CeeNU, Gleostine
Lomustine is dosed at 60–90 mg/m2 PO q3-6 weeks in dogs, per Dobson J, Lascelles D. BSAVA Manual of Canine and Feline Oncology. BSAVA; 2011. — Verified against Plumb's Veterinary Drug Handbook, 10th Ed, p.801 (2026-08-01).. Verify against current literature before clinical use.
Lipophilic nitrosourea that crosses BBB. Alkylates DNA and RNA. Forms DNA interstrand crosslinks and carbamylates proteins.
Severe delayed myelosuppression (nadir 4-6 weeks). CUMULATIVE hepatotoxicity — monitor liver enzymes before every dose. Used for mast cell tumors, lymphoma, brain tumors. Handle with gloves.
Species references:All Dog (Domestic) drugs
Each ExoticRx dose rule is graded by the strength of its primary evidence — see the editorial process.
A dog/cat sample is shown here. Cited dosing for all 1 species — reptiles, birds, pocket pets, livestock, and equine — is free on the per-species pages above. Pro adds the weight-based calculator for every species.
| Species | Route | Dose | Frequency | Evidence | Source |
|---|---|---|---|---|---|
| Dog (Domestic) | PO | 60–90 mg/m2 | q3-6 weeks | Strong | Dobson J, Lascelles D. BSAVA Manual of Canine and Feline Oncology. BSAVA; 2011. — Verified against Plumb's Veterinary Drug Handbook, 10th Ed, p.801 (2026-08-01). |
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View PlansSource citations and evidence levels available on the live page. Reference only — verify against current literature before clinical use.