Dog · Canis lupus familiaris · typical adult weight 2.00–80.00 kg
Lomustine is dosed at 60–90 mg/m2 PO q3-6 weeks in dogs, per Dobson J, Lascelles D. BSAVA Manual of Canine and Feline Oncology. BSAVA; 2011. — Verified against Plumb's Veterinary Drug Handbook, 10th Ed, p.801 (2026-08-01).. Lomustine is used in dogs for Mast cell tumors, lymphoma, brain tumors. Routes documented in dogs: PO. A typical adult dog weighs 2.00–80.00 kg. ExoticRx lists 1 cited dose rule for Lomustine in dogs, drawn from published veterinary references. Verify against current literature before clinical use.
US trade names: CeeNU, Gleostine
| Route | Dose | Frequency | Duration | Indication | Evidence | Source |
|---|---|---|---|---|---|---|
| PO | 60–90 mg/m2 | q3-6 weeks | 4-6 cycles | Mast cell tumors, lymphoma, brain tumors | Strong | Dobson J, Lascelles D. BSAVA Manual of Canine and Feline Oncology. BSAVA; 2011. — Verified against Plumb's Veterinary Drug Handbook, 10th Ed, p.801 (2026-08-01). |
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Enter your dog's weight to check these cited ranges in the calculator — unit and concentration math done for you.
Lipophilic nitrosourea that crosses BBB. Alkylates DNA and RNA. Forms DNA interstrand crosslinks and carbamylates proteins.
Severe delayed myelosuppression (nadir 4-6 weeks). CUMULATIVE hepatotoxicity — monitor liver enzymes before every dose. Used for mast cell tumors, lymphoma, brain tumors. Handle with gloves.
Species-specific contraindications and adverse-reaction reports for dogs may differ from canine / feline reference data — consult the primary citations listed with each rule.
Lomustine dose range in dogs, with cited source references: PO 60–90 mg/m2 q3-6 weeks. Reference ranges from cited sources — verify against current literature before clinical use.
Documented routes for Lomustine in dogs: PO.
Cited course lengths for Lomustine in dogs include: 4-6 cycles. Duration depends on the indication — match it to the specific dose rule in the table above.
Lomustine is indicated in dogs for: Mast cell tumors, lymphoma, brain tumors.
These are general warnings for Lomustine across species; consult the dog dosing table above for species-specific guidance. Severe delayed myelosuppression (nadir 4-6 weeks). CUMULATIVE hepatotoxicity — monitor liver enzymes before every dose. Used for mast cell tumors, lymphoma, brain tumors. Handle with gloves.
Why a species-specific page? Lomustine pharmacokinetics differ across species: dose ranges, intervals, and route preferences are not interchangeable. Cross-extrapolation from canine doses is unsafe in dogs — the rules above are the citations specific to this species, not generic recommendations.
Sourced from published veterinary references; awaiting credentialed clinical reviewer. See our editorial process. Reference only — not veterinary advice.