Dog · Canis lupus familiaris · typical adult weight 2.00–80.00 kg
Lomustine is dosed at 60–90 mg/m2 PO q3-6 weeks in dogs, per Dobson J, Lascelles D. BSAVA Manual of Canine and Feline Oncology. BSAVA; 2011. — Verified against Plumb's Veterinary Drug Handbook, 10th Ed, p.801 (2026-08-01). — Plumb's 10th ed (held) printed p.773, Lomustine monograph spanning p.773-774; page located 2026-08-05 from the book's own running heads, verified to name the drug in its body text. — SOURCE EDITION: BSAVA Small Animal Formulary, Part A — Canine and Feline — ISBN 9781910443705, https://openlibrary.org/isbn/9781910443705; Plumb's Veterinary Drug Handbook — ISBN 9781394172207, https://openlibrary.org/isbn/9781394172207. Lomustine is used in dogs for Mast cell tumors, lymphoma, brain tumors. Routes documented in dogs: PO. A typical adult dog weighs 2.00–80.00 kg. ExoticRx lists 1 cited dose rule for Lomustine in dogs, drawn from published veterinary references. Verify against current literature before clinical use.
US trade names: CeeNU, Gleostine
| Route | Dose | Frequency | Duration | Indication | Evidence | Source |
|---|---|---|---|---|---|---|
| PO | 60–90 mg/m2 | q3-6 weeks | 4-6 cycles | Mast cell tumors, lymphoma, brain tumors | Strong | Dobson J, Lascelles D. BSAVA Manual of Canine and Feline Oncology. BSAVA; 2011. — Verified against Plumb's Veterinary Drug Handbook, 10th Ed, p.801 (2026-08-01). — Plumb's 10th ed (held) printed p.773, Lomustine monograph spanning p.773-774; page located 2026-08-05 from the book's own running heads, verified to name the drug in its body text. — SOURCE EDITION: BSAVA Small Animal Formulary, Part A — Canine and Feline — ISBN 9781910443705, https://openlibrary.org/isbn/9781910443705; Plumb's Veterinary Drug Handbook — ISBN 9781394172207, https://openlibrary.org/isbn/9781394172207 |
Every held source for this drug and species, as printed. Where they differ, both are shown — the choice is yours, not ours.
| Dose (mg/m2) | Route | Source | As printed |
|---|---|---|---|
| 70–90 | PO | Papich Saunders Handbook of Veterinary Drugs, 4th edp.485 | • 70-90 mg/m2 q4wk PO. |
| 60 | — | Papich Saunders Handbook of Veterinary Drugs, 4th edp.485 | • Lymphoma: 60 mg/m2 q4wk, for four treatments. |
| 60–80 | PO | Papich Saunders Handbook of Veterinary Drugs, 4th edp.485 | • Brain tumors: 60-80 mg/m2 q6-8wk PO. |
| 40 | — | Papich Saunders Handbook of Veterinary Drugs, 4th edp.485 | • Where liver injury is a concern in dogs, use a lower and safer dose of 40 mg/m2. |
Figures are transcribed from the cited page or table of each held edition and are shown for reference only. They are not dose recommendations, they do not feed the calculator, and none has been reviewed by a veterinarian.
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Lipophilic nitrosourea that crosses BBB. Alkylates DNA and RNA. Forms DNA interstrand crosslinks and carbamylates proteins.
Severe delayed myelosuppression (nadir 4-6 weeks). CUMULATIVE hepatotoxicity — monitor liver enzymes before every dose. Used for mast cell tumors, lymphoma, brain tumors. Handle with gloves.
Species-specific contraindications and adverse-reaction reports for dogs may differ from canine / feline reference data — consult the primary citations listed with each rule.
Lomustine dose range in dogs, with cited source references: PO 60–90 mg/m2 q3-6 weeks. Reference ranges from cited sources — verify against current literature before clinical use.
Documented routes for Lomustine in dogs: PO.
Cited course lengths for Lomustine in dogs include: 4-6 cycles. Duration depends on the indication — match it to the specific dose rule in the table above.
Lomustine is indicated in dogs for: Mast cell tumors, lymphoma, brain tumors.
These are general warnings for Lomustine across species; consult the dog dosing table above for species-specific guidance. Severe delayed myelosuppression (nadir 4-6 weeks). CUMULATIVE hepatotoxicity — monitor liver enzymes before every dose. Used for mast cell tumors, lymphoma, brain tumors. Handle with gloves.
Why a species-specific page? Lomustine pharmacokinetics differ across species: dose ranges, intervals, and route preferences are not interchangeable. Cross-extrapolation from canine doses is unsafe in dogs — the rules above are the citations specific to this species, not generic recommendations.
Sourced from published veterinary references; awaiting credentialed clinical reviewer. See our editorial process. Reference only — not veterinary advice.