Dog · Canis lupus familiaris · typical adult weight 2.00–80.00 kg
Marbofloxacin is dosed at 2–5 mg/kg IV q24h in dogs, per Plumb's Veterinary Drug Handbook, 9th Ed. Marbofloxacin is used in dogs for Severe systemic infections, Skin infections, UTI, respiratory, Complicated UTI (Pseudomonas), Otitis externa (systemic component). Routes documented in dogs: IV, PO. A typical adult dog weighs 2.00–80.00 kg. ExoticRx lists 5 cited dose rules for Marbofloxacin in dogs, drawn from published veterinary references. Verify against current literature before clinical use.
US trade names: Zeniquin
| Route | Dose | Frequency | Duration | Indication | Evidence | Source |
|---|---|---|---|---|---|---|
| IV | 2–5 mg/kg | q24h | Until oral feasible | Severe systemic infections | Moderate | Plumb's Veterinary Drug Handbook, 9th Ed |
| PO | 2.75–5.5 mg/kg | q24h | 7-14 days | Skin infections, UTI, respiratory | Strong | ZENIQUIN - Marbofloxacin Tablet [US Product Label for Dogs and Cats]. Zoetis Inc.; 2019. https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=05196313-2371-45ad-a6fb-6269f8ef94c5 — Verified against Plumb's Veterinary Drug Handbook, 10th Ed, p.824 (2026-08-01). |
| PO | 5.5 mg/kg | q24h | 14-28 days | Complicated UTI (Pseudomonas) | Strong | Cole L. Pseudomonas otitis: diagnosis, treatment, and prognosis. Presented at: AVA; 2008. — Verified against Plumb's Veterinary Drug Handbook, 10th Ed, p.824 (2026-08-01). |
| PO | 2.75–5.5 mg/kg | q24h | 14-21 days | Otitis externa (systemic component) | Moderate | ZENIQUIN - Marbofloxacin Tablet [US Product Label for Dogs and Cats]. Zoetis Inc.; 2019. https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=05196313-2371-45ad-a6fb-6269f8ef94c5 — Verified against Plumb's Veterinary Drug Handbook, 10th Ed, p.824 (2026-08-01). |
| PO | 5.5 mg/kg | q24h | 6-8 weeks | Deep pyoderma (Pseudomonas-associated) | Moderate | Cole L. Pseudomonas otitis: diagnosis, treatment, and prognosis. Presented at: AVA; 2008. — Verified against Plumb's Veterinary Drug Handbook, 10th Ed, p.824 (2026-08-01). |
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These ranges are per kg. Enter your dog's weight to get the precise dose and draw-up volume — unit and concentration math done for you.
Inhibits bacterial DNA gyrase and topoisomerase IV, preventing DNA replication. Concentration-dependent bactericidal.
Avoid in growing animals (cartilage damage). May lower seizure threshold. Avoid concurrent NSAIDs in dehydrated patients.
Species-specific contraindications and adverse-reaction reports for dogs may differ from canine / feline reference data — consult the primary citations listed with each rule.
Marbofloxacin dose ranges in dogs, with cited source references: IV 2–5 mg/kg q24h; PO 2.75–5.5 mg/kg q24h; PO 5.5 mg/kg q24h; PO 2.75–5.5 mg/kg q24h. Reference ranges from cited sources — verify against current literature before clinical use.
Documented routes for Marbofloxacin in dogs: IV, PO.
Cited course lengths for Marbofloxacin in dogs include: Until oral feasible; 7-14 days; 14-28 days; 14-21 days. Duration depends on the indication — match it to the specific dose rule in the table above.
Marbofloxacin is indicated in dogs for: Severe systemic infections, Skin infections, UTI, respiratory, Complicated UTI (Pseudomonas), Otitis externa (systemic component), Deep pyoderma (Pseudomonas-associated).
These are general warnings for Marbofloxacin across species; consult the dog dosing table above for species-specific guidance. Avoid in growing animals (cartilage damage). May lower seizure threshold. Avoid concurrent NSAIDs in dehydrated patients.
Why a species-specific page? Marbofloxacin pharmacokinetics differ across species: dose ranges, intervals, and route preferences are not interchangeable. Cross-extrapolation from canine doses is unsafe in dogs — the rules above are the citations specific to this species, not generic recommendations.
Sourced from published veterinary references; awaiting credentialed clinical reviewer. See our editorial process. Reference only — not veterinary advice.