What is Marbofloxacin used for?

Marbofloxacin is indicated for: Antimicrobial, Bacterial infection (fluoroquinolone), Bacterial infection (row states no indication), Bacterial infections, Complicated UTI (Pseudomonas), Feline lower urinary tract disease (bacterial), respiratory, See source, Severe systemic infections, Skin infections, Susceptible Gram-negative bacterial infection, UTI.

Which species have cited Marbofloxacin dosing data?

Marbofloxacin dosing in the ExoticRx formulary covers 20 species: African Grey Parrot, Ball Python, Blue-and-Gold Macaw, Cat (Domestic), Chinchilla, Degu, Dog (Domestic), Dwarf Hamster, Gerbil, Goose, Great Horned Owl, Guinea Pig, Harris Hawk, Mouse, Peregrine Falcon, Pet Rat, Rabbit (Domestic), Red-eared Slider, Red-tailed Hawk, Sugar Glider.

Is Marbofloxacin a controlled substance?

Marbofloxacin is not federally scheduled in the US. Controlled-drug status differs by country — verify your local rules.

What are the warnings or contraindications for Marbofloxacin?

Avoid in growing animals (cartilage damage). May lower seizure threshold. Avoid concurrent NSAIDs in dehydrated patients.

What are the side effects of Marbofloxacin?

Reported side effects, adverse reactions, and contraindications for Marbofloxacin: Avoid in growing animals (cartilage damage). May lower seizure threshold. Avoid concurrent NSAIDs in dehydrated patients.

How does Marbofloxacin work?

Inhibits bacterial DNA gyrase and topoisomerase IV, preventing DNA replication. Concentration-dependent bactericidal.

Marbofloxacin

US brand names:Zeniquin

Calculate dosage

Sourced from published veterinary references. Awaiting credentialed clinical reviewer — our editorial process.

Marbofloxacin is dosed at 10 mg/kg PO q48h in ball pythons, per Coke RL, Isaza R, Koch DE, et al. Preliminary single-dose pharmacokinetics of marbofloxacin in ball pythons (Python regius). J Zoo Wildl Med. 2006;37:6-10. — Source: Carpenter's Exotic Animal Formulary, 6th Ed, p.217 — Carpenter's Exotic Animal Formulary 6th ed, Table 4.1 (Antimicrobial Agents Used in Reptiles.a,b). The copy held is an ebook conversion with no printed page numbers, so the table — not the page — is the citable location. — CORROBORATED 2026-08-06 by independent literature: Preliminary single-dose pharmacokinetics of marbofloxacin in ball pythons (Python regius). (Journal of zoo and wildlife medicine : official publication of the American Association of Zoo Veterinarians, 2006). doi:10.1638/04-102.1. https://doi.org/10.1638/04-102.1. The paper reports this drug at this dose in this species: "adult ball pythons (Python regius) was determined after i.v. and p.o. administration of a single […]". This is a second source alongside the book already cited; it corroborates the figure and does not by itself establish that the dose is correct. — SOURCE EDITION: Carpenter's Exotic Animal Formulary — ISBN 9780323833929, https://openlibrary.org/isbn/9780323833929. Verify against current literature before clinical use.

Backed by 17 published sources

· 122. Meredith A. BSAVA Small Animal Formulary: Part B: Exotic Pets, British Small Animal Veterinary Association, Quedgeley, Gloucester, UK; 2015. — Source: Carpenter's Exotic Animal Formulary, 6th Ed, p.772 — Carpenter's Exotic Animal Formulary 6th ed, Table 9.1 (Antimicrobial and Antifungal Agents Used in Rodents.a). The copy held is an ebook conversion with no printed page numbers, so the table — not the page — is the citable location. — SOURCE EDITION: BSAVA Small Animal Formulary, Part B — Exotic Pets — ISBN 9781910443712, https://openlibrary.org/isbn/9781910443712; Carpenter's Exotic Animal Formulary — ISBN 9780323833929, https://openlibrary.org/isbn/9780323833929
· Abo-EL-Sooud K, Swielim GA, EL-Gammal SM, et al. Comparative Pharmacokinetics and bioavailability of marbofloxacin in geese (Anser anser domesticus) after two sites of intramuscular administrations. J Vet Pharmacol Ther. 2020;43(4):313-318. doi:10.1111/jvp.12853 — PRINTED DETAIL MISSING FROM THIS RULE (retrieved 2026-08-19): We recommend the thigh muscle as IM site of injection to obtain maximum concentrations of the administered drug in geese. — Abo-El-Sooud et al, J Vet Pharmacol Ther 2020;43(4):313-318, ; missing: 21 CFR 530.41(a) "The following drugs … are prohibited for extralabel animal and human drug uses in food-producing animals" — "(10) Fluoroquinolones"

Sample dosing (2 of 26 cited rules)

A dog/cat sample is shown here. Cited dosing for all 20 species — reptiles, birds, pocket pets, livestock, and equine — is free on the per-species pages above. Pro adds the weight-based calculator for every species.

Species	Route	Dose	Frequency	Evidence	Source
Dog (Domestic)	PO	5.5 mg/kg	q24h	Strong	Cole L. Pseudomonas otitis: diagnosis, treatment, and prognosis. Presented at: AVA; 2008. — Verified against Plumb's Veterinary Drug Handbook, 10th Ed, p.824 (2026-08-01). — Plumb's 10th ed (held) printed p.797, Marbofloxacin monograph spanning p.796-798; page located 2026-08-05 from the book's own running heads, and carries this exact dose under the matching species heading. — SOURCE EDITION: Plumb's Veterinary Drug Handbook — ISBN 9781394172207, https://openlibrary.org/isbn/9781394172207
Cat (Domestic)	PO	2.75–5.5 mg/kg	q24h	Strong	ZENIQUIN - Marbofloxacin Tablet [US Product Label for Dogs and Cats]. Zoetis Inc.; 2019. https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=05196313-2371-45ad-a6fb-6269f8ef94c5 — Verified against Plumb's Veterinary Drug Handbook, 10th Ed, p.825 (2026-08-01). — Plumb's 10th ed (held) printed p.797, Marbofloxacin monograph spanning p.796-798; page located 2026-08-05 from the book's own running heads, and carries this exact dose under the matching species heading. — SOURCE EDITION: Plumb's Veterinary Drug Handbook — ISBN 9781394172207,

· Carpenter Exotic Animal Formulary 6th ed, Table 5.1 (Antimicrobial Agents Used in Birds), Marbofloxacin block. The row is printed for BLUE AND GOLD MACAWS and is framed /PK. 146. Carpenter JW, Hunter RP, Olsen JH, et al. Pharmacokinetics of marbofloxacin in blue and gold macaws (Ara ararauna). Am J Vet Res. 2006 -- 67:947-950. EXTRAPOLATED to African grey parrot: no held text prints a marbofloxacin dose for Psittacus erithacus. The held copy is an ebook with no printed pagination, so the TABLE is the citable location.

· Carpenter JW, Hunter RP, Olsen JH, et al. Pharmacokinetics of marbofloxacin in blue and gold macaws (Ara ararauna). Am J Vet Res. 2006;67:947-950. doi:10.2460/ajvr.67.6.947 — Verified against Carpenter's Exotic Animal Formulary, 6th Ed, p.417 (2026-08-01). — SOURCE EDITION: Carpenter's Exotic Animal Formulary — ISBN 9780323833929, https://openlibrary.org/isbn/9780323833929

· Carpenter JW, Pollock CG, Koch DE, et al. Single- and multiple-dose pharmacokinetics of marbofloxacin after oral administration to rabbits. Am J Vet Res. 2009;70:522-526. doi:10.2460/ajvr.70.4.522 — Verified against Carpenter's Exotic Animal Formulary, 6th Ed, p.843 (2026-08-01). — SOURCE EDITION: Carpenter's Exotic Animal Formulary — ISBN 9780323833929, https://openlibrary.org/isbn/9780323833929

· Coke RL, Isaza R, Koch DE, et al. Preliminary single-dose pharmacokinetics of marbofloxacin in ball pythons (Python regius). J Zoo Wildl Med. 2006;37:6-10. — Source: Carpenter's Exotic Animal Formulary, 6th Ed, p.217 — Carpenter's Exotic Animal Formulary 6th ed, Table 4.1 (Antimicrobial Agents Used in Reptiles.a,b). The copy held is an ebook conversion with no printed page numbers, so the table — not the page — is the citable location. — CORROBORATED 2026-08-06 by independent literature: Preliminary single-dose pharmacokinetics of marbofloxacin in ball pythons (Python regius). (Journal of zoo and wildlife medicine : official publication of the American Association of Zoo Veterinarians, 2006). doi:10.1638/04-102.1. https://doi.org/10.1638/04-102.1. The paper reports this drug at this dose in this species: "adult ball pythons (Python regius) was determined after i.v. and p.o. administration of a single […]". This is a second source alongside the book already cited; it corroborates the figure and does not by itself establish that the dose is correct. — SOURCE EDITION: Carpenter's Exotic Animal Formulary — ISBN 9780323833929, https://openlibrary.org/isbn/9780323833929

· Cole L. Pseudomonas otitis: diagnosis, treatment, and prognosis. Presented at: AVA; 2008. — Verified against Plumb's Veterinary Drug Handbook, 10th Ed, p.824 (2026-08-01). — Plumb's 10th ed (held) printed p.797, Marbofloxacin monograph spanning p.796-798; page located 2026-08-05 from the book's own running heads, and carries this exact dose under the matching species heading. — SOURCE EDITION: Plumb's Veterinary Drug Handbook — ISBN 9781394172207, https://openlibrary.org/isbn/9781394172207

· Hedley J. BSAVA Small Animal Formulary. Part B: Exotic Pets, 10th ed., British Small Animal Veterinary Association — Verified against Carpenter's Exotic Animal Formulary, 6th Ed, p.704 (2026-08-01). — Carpenter's Exotic Animal Formulary 6th ed, Table 7.1 (Antimicrobial and Antifungal Agents Used in Sugar Gliders). The copy held is an ebook conversion with no printed page numbers, so the table — not the page — is the citable location. — SOURCE EDITION: BSAVA Small Animal Formulary, Part B — Exotic Pets — ISBN 9781910443712, https://openlibrary.org/isbn/9781910443712; Carpenter's Exotic Animal Formulary — ISBN 9780323833929, https://openlibrary.org/isbn/9780323833929

· Lai OR, Marin P, Laricchiuta P, et al. Pharmacokinetics of injectable marbofloxacin after intravenous and intramuscular administration in red-eared sliders (Trachemys scripta elegans). J Vet Pharmacol Ther. 2020;43:129-134. — Source: Carpenter's Exotic Animal Formulary, 6th Ed, p.218 — Carpenter's Exotic Animal Formulary 6th ed, Table 4.1 (Antimicrobial Agents Used in Reptiles.a,b). The copy held is an ebook conversion with no printed page numbers, so the table — not the page — is the citable location. — CORROBORATED 2026-08-06 by independent literature: Pharmacokinetics of injectable marbofloxacin after intravenous and intramuscular administration in red-eared sliders (Trachemys scripta elegans). (Journal of veterinary pharmacology and therapeutics, 2020). doi:10.1111/jvp.12803. https://doi.org/10.1111/jvp.12803. The paper reports this drug at this dose in this species: "of their broad spectrum of activity including the most frequent pathogens of these species. The […]". This is a second source alongside the book already cited; it corroborates the figure and does not by itself establish that the dose is correct. — SOURCE EDITION: Carpenter's Exotic Animal Formulary — ISBN 9780323833929, ; Veterinary Pharmacology and Therapeutics — ISBN 9781118855829, — INTERVAL IS PRINTED: Mader's Reptile Medicine and Surgery 3rd ed, Table 116.7 ("Peer-Reviewed Fluoroquinolones Pharmacokinetic Data in Reptile Species to Utilize in Clinical Practice"), printed p.1152 — red-eared slider, 2 mg/kg, IV and IM, "Recommended Frequency of Administration 24 hrs".

· Lai OR, Marín P, Laricchiuta P, Gelli D, Escudero E, Crescenzo G. Pharmacokinetics of injectable marbofloxacin after intravenous and intramuscular administration in red-eared sliders (Trachemys scripta elegans). J Vet Pharmacol Ther. 2020;43(2):129-134. doi:10.1111/jvp.12803 https://europepmc.org/abstract/MED/31393637 — INTERVAL IS PRINTED: Mader's Reptile Medicine and Surgery 3rd ed, Table 116.7 ("Peer-Reviewed Fluoroquinolones Pharmacokinetic Data in Reptile Species to Utilize in Clinical Practice"), printed p.1152 — red-eared slider, 2 mg/kg, IV and IM, "Recommended Frequency of Administration 24 hrs".

· Meredith A. BSAVA Small Animal Formulary: Part B: Exotic Pets, British Small Animal Veterinary Association, Quedgeley, Gloucester, UK; 2015. — Source: Carpenter's Exotic Animal Formulary, 6th Ed, p.772 — Carpenter's Exotic Animal Formulary 6th ed, Table 9.1 (Antimicrobial and Antifungal Agents Used in Rodents.a). The copy held is an ebook conversion with no printed page numbers, so the table — not the page — is the citable location. — SOURCE EDITION: BSAVA Small Animal Formulary, Part B — Exotic Pets — ISBN 9781910443712, https://openlibrary.org/isbn/9781910443712; Carpenter's Exotic Animal Formulary — ISBN 9780323833929, https://openlibrary.org/isbn/9780323833929

· Meredith A. BSAVA Small Animal Formulary: Part B: Exotic Pets, British Small Animal Veterinary Association, Quedgeley, Gloucester, UK; 2015. — Verified against Carpenter's Exotic Animal Formulary, 6th Ed, p.772 (2026-08-01). — Carpenter's Exotic Animal Formulary 6th ed, Table 9.1 (Antimicrobial and Antifungal Agents Used in Rodents.a). The copy held is an ebook conversion with no printed page numbers, so the table — not the page — is the citable location. — SOURCE EDITION: BSAVA Small Animal Formulary, Part B — Exotic Pets — ISBN 9781910443712, https://openlibrary.org/isbn/9781910443712; Carpenter's Exotic Animal Formulary — ISBN 9780323833929, https://openlibrary.org/isbn/9780323833929

· Plumb's Veterinary Drug Handbook, 10th ed (2023, held copy; the original seed cited the 9th, which was never consulted) — Plumb's 10th ed (held) printed p.796, Marbofloxacin monograph spanning p.796-798; page located 2026-08-05 from the book's own running heads, verified to name the drug in its body text. — SOURCE EDITION: Plumb's Veterinary Drug Handbook — ISBN 9781394172207, https://openlibrary.org/isbn/9781394172207 — BSAVA Small Animal Formulary, 10th ed, Part A — Canine and Feline, Marbofloxacin, DOSES, printed p.243 (corpus PDF p.259): "Dogs: Oral and parenteral: 2 mg/kg i.v., s.c., p.o. q24h."; Formulations, printed p.242: "Injectable: 200 mg powder for reconstitution giving 10 mg/ml when reconstituted." [CEILING REDUCED 2026-08-12, two readers — Plumb's printed p.796-798 prints every canine marbofloxacin dose as oral and lists no injectable product, stating "Parenteral formulation is not available in the United States"; Papich printed p.473 likewise prints oral figures only; DailyMed carries no US marbofloxacin injectable label. No retrieved document prints 5 mg/kg IV for a dog.] — SOURCE EDITION: BSAVA Small Animal Formulary, Part A — Canine and Feline — ISBN 9781910443705, https://openlibrary.org/isbn/9781910443705

· Samour, Avian Medicine, 3rd Ed. (raptor formulary appendix), p.654. Row as printed binds this dose to raptors on its own line: "Marbofloxacin Marbocyl 2% and Raptors IV, IM, PO 5-10 mg/kg bid for 5-7 d As for enrofloxacin but less likely to cause". Located by line-level extraction and then read on the page; the species binding is the row's own species column, not text proximity.

· ZENIQUIN - Marbofloxacin Tablet [US Product Label for Dogs and Cats]. Zoetis Inc.; 2019. https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=05196313-2371-45ad-a6fb-6269f8ef94c5 — Verified against Plumb's Veterinary Drug Handbook, 10th Ed, p.824 (2026-08-01). — Plumb's 10th ed (held) printed p.797, Marbofloxacin monograph spanning p.796-798; page located 2026-08-05 from the book's own running heads, and carries this exact dose under the matching species heading. — SOURCE EDITION: Plumb's Veterinary Drug Handbook — ISBN 9781394172207, https://openlibrary.org/isbn/9781394172207

Marbofloxacin

Drug Class

Routes

Indications

Mechanism of Action

Side effects & warnings

Species with Marbofloxacin dosing data (26 dose rules)

Evidence levels across 26 dose rules

Backed by 17 published sources

Sample dosing (2 of 26 cited rules)

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Other formulations of Marbofloxacin

Marbofloxacin

Drug Class

Routes

Indications

Mechanism of Action

Side effects & warnings

Species with Marbofloxacin dosing data (26 dose rules)

Evidence levels across 26 dose rules

Backed by 17 published sources

Sample dosing (2 of 26 cited rules)

Upgrade for Full Details

Other formulations of Marbofloxacin

Articles mentioning Marbofloxacin

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