ExoticRx · exoticrx.com/drugs/methotrexate
US brand names:Trexall
Methotrexate is dosed at 0.6–0.8 mg/kg IV Per protocol in dogs, per USPC. Veterinary Information- Appendix III. 1990;2:2811-2860. — Verified against Plumb's Veterinary Drug Handbook, 10th Ed, p.885 (2026-08-01).. Verify against current literature before clinical use.
Inhibits dihydrofolate reductase, blocking thymidylate and purine synthesis. Impairs DNA replication in rapidly dividing cells.
Myelosuppression, GI toxicity (mucositis, diarrhea), hepatotoxicity, nephrotoxicity. Leucovorin rescue may be needed. Not commonly used as single agent in veterinary oncology. Monitor CBC and renal function.
Species references:All Dog (Domestic) drugs
Each ExoticRx dose rule is graded by the strength of its primary evidence — see the editorial process.
A dog/cat sample is shown here. Cited dosing for all 1 species — reptiles, birds, pocket pets, livestock, and equine — is free on the per-species pages above. Pro adds the weight-based calculator for every species.
| Species | Route | Dose | Frequency | Evidence | Source |
|---|---|---|---|---|---|
| Dog (Domestic) | IV | 0.6–0.8 mg/kg | Per protocol | Weak | USPC. Veterinary Information- Appendix III. 1990;2:2811-2860. — Verified against Plumb's Veterinary Drug Handbook, 10th Ed, p.885 (2026-08-01). |
Upgrade to Pro or Student to unlock the full dose ranges and frequency for every species. The drug's mechanism, warnings, indications, and cited sources are free to read.
View PlansSource citations and evidence levels available on the live page. Reference only — verify against current literature before clinical use.