Dog · Canis lupus familiaris · typical adult weight 2.00–80.00 kg
Methotrexate is dosed at 0.6–0.8 mg/kg IV Per protocol in dogs, per USPC. Veterinary Information- Appendix III. 1990;2:2811-2860. — Verified against Plumb's Veterinary Drug Handbook, 10th Ed, p.885 (2026-08-01). — Plumb's 10th ed (held) printed p.856, Methotrexate monograph spanning p.856-858; page located 2026-08-05 from the book's own running heads, verified to name the drug in its body text. — SOURCE EDITION: Plumb's Veterinary Drug Handbook — ISBN 9781394172207, https://openlibrary.org/isbn/9781394172207. Methotrexate is used in dogs for Lymphoma (rescue protocol component). Routes documented in dogs: IV. A typical adult dog weighs 2.00–80.00 kg. ExoticRx lists 1 cited dose rule for Methotrexate in dogs, drawn from published veterinary references. Verify against current literature before clinical use.
US trade names: Trexall
| Route | Dose | Frequency | Duration | Indication | Evidence | Source |
|---|---|---|---|---|---|---|
| IV | 0.6–0.8 mg/kg | Per protocol | Per rescue protocol | Lymphoma (rescue protocol component) | Weak | USPC. Veterinary Information- Appendix III. 1990;2:2811-2860. — Verified against Plumb's Veterinary Drug Handbook, 10th Ed, p.885 (2026-08-01). — Plumb's 10th ed (held) printed p.856, Methotrexate monograph spanning p.856-858; page located 2026-08-05 from the book's own running heads, verified to name the drug in its body text. — SOURCE EDITION: Plumb's Veterinary Drug Handbook — ISBN 9781394172207, https://openlibrary.org/isbn/9781394172207 |
Every held source for this drug and species, as printed. Where they differ, both are shown — the choice is yours, not ours.
| Dose (mg/kg) | Route | Source | As printed |
|---|---|---|---|
| 0.3–0.5 | IV | Papich Saunders Handbook of Veterinary Drugs, 4th edp.540 | • 0.3-0.5 mg/kg every week IV. |
| Dose (mg/m2) | Route | Source | As printed |
|---|---|---|---|
| 2.5–5 | PO | Papich Saunders Handbook of Veterinary Drugs, 4th edp.540 | • 2.5-5 mg/m2 q48h PO (dose depends on specific cancer protocol). |
Figures are transcribed from the cited page or table of each held edition and are shown for reference only. They are not dose recommendations, they do not feed the calculator, and none has been reviewed by a veterinarian.
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Inhibits dihydrofolate reductase, blocking thymidylate and purine synthesis. Impairs DNA replication in rapidly dividing cells.
Myelosuppression, GI toxicity (mucositis, diarrhea), hepatotoxicity, nephrotoxicity. Leucovorin rescue may be needed. Not commonly used as single agent in veterinary oncology. Monitor CBC and renal function.
Species-specific contraindications and adverse-reaction reports for dogs may differ from canine / feline reference data — consult the primary citations listed with each rule.
Methotrexate dose range in dogs, with cited source references: IV 0.6–0.8 mg/kg Per protocol. Reference ranges from cited sources — verify against current literature before clinical use.
Documented routes for Methotrexate in dogs: IV.
Cited course lengths for Methotrexate in dogs include: Per rescue protocol. Duration depends on the indication — match it to the specific dose rule in the table above.
Methotrexate is indicated in dogs for: Lymphoma (rescue protocol component).
These are general warnings for Methotrexate across species; consult the dog dosing table above for species-specific guidance. Myelosuppression, GI toxicity (mucositis, diarrhea), hepatotoxicity, nephrotoxicity. Leucovorin rescue may be needed. Not commonly used as single agent in veterinary oncology. Monitor CBC and renal function.
Why a species-specific page? Methotrexate pharmacokinetics differ across species: dose ranges, intervals, and route preferences are not interchangeable. Cross-extrapolation from canine doses is unsafe in dogs — the rules above are the citations specific to this species, not generic recommendations.
Sourced from published veterinary references; awaiting credentialed clinical reviewer. See our editorial process. Reference only — not veterinary advice.