Dog · Canis lupus familiaris · typical adult weight 2.00–80.00 kg
Metolazone is dosed at 0.1–0.5 mg/kg PO q12-24h in dogs, per Plumb's Veterinary Drug Handbook, 9th Ed. Metolazone is used in dogs for Refractory congestive heart failure (diuretic synergy). Routes documented in dogs: PO. A typical adult dog weighs 2.00–80.00 kg. ExoticRx lists 1 cited dose rule for Metolazone in dogs, drawn from published veterinary references. Verify against current literature before clinical use.
US trade names: Zaroxolyn
| Route | Dose | Frequency | Duration | Indication | Evidence | Source |
|---|---|---|---|---|---|---|
| PO | 0.1–0.5 mg/kg | q12-24h | Short-term pulses (2-3 days) or PRN; severe electrolyte risk with continuous use | Refractory congestive heart failure (diuretic synergy) | Moderate | Plumb's Veterinary Drug Handbook, 9th Ed |
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Quinazoline diuretic that inhibits sodium reabsorption in the distal convoluted tubule. Retains efficacy in renal impairment unlike true thiazides.
Potent diuretic synergy with loop diuretics — severe electrolyte depletion. Monitor potassium, sodium, magnesium. Used for furosemide-resistant CHF.
Species-specific contraindications and adverse-reaction reports for dogs may differ from canine / feline reference data — consult the primary citations listed with each rule.
Metolazone dose range in dogs, with cited source references: PO 0.1–0.5 mg/kg q12-24h. Reference ranges from cited sources — verify against current literature before clinical use.
Documented routes for Metolazone in dogs: PO.
Cited course lengths for Metolazone in dogs include: Short-term pulses (2-3 days) or PRN; severe electrolyte risk with continuous use. Duration depends on the indication — match it to the specific dose rule in the table above.
Metolazone is indicated in dogs for: Refractory congestive heart failure (diuretic synergy).
These are general warnings for Metolazone across species; consult the dog dosing table above for species-specific guidance. Potent diuretic synergy with loop diuretics — severe electrolyte depletion. Monitor potassium, sodium, magnesium. Used for furosemide-resistant CHF.
Why a species-specific page? Metolazone pharmacokinetics differ across species: dose ranges, intervals, and route preferences are not interchangeable. Cross-extrapolation from canine doses is unsafe in dogs — the rules above are the citations specific to this species, not generic recommendations.
Sourced from published veterinary references; awaiting credentialed clinical reviewer. See our editorial process. Reference only — not veterinary advice.