Dog · Canis lupus familiaris · typical adult weight 2.00–80.00 kg
Metolazone is used in dog for Refractory congestive heart failure (diuretic synergy). Routes documented in dog: PO. A typical adult dog weighs 2.00–80.00 kg. ExoticRx lists 1 cited dose rule for Metolazone in dog, drawn from published veterinary references. Verify against current literature before clinical use.
Trade names: Zaroxolyn
| Route | Dose | Frequency | Duration | Indication | Evidence | Source |
|---|---|---|---|---|---|---|
| PO | 0.1–0.5 mg/kg | q12-24h | Short-term pulses (2-3 days) or PRN; severe electrolyte risk with continuous use | Refractory congestive heart failure (diuretic synergy) | Moderate | Plumb's Veterinary Drug Handbook, 9th Ed |
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These ranges are per kg. Enter your dog's weight to get the precise dose and draw-up volume — unit and concentration math done for you.
Quinazoline diuretic that inhibits sodium reabsorption in the distal convoluted tubule. Retains efficacy in renal impairment unlike true thiazides.
Potent diuretic synergy with loop diuretics — severe electrolyte depletion. Monitor potassium, sodium, magnesium. Used for furosemide-resistant CHF.
Species-specific contraindications and adverse-reaction reports for dog may differ from canine / feline reference data — consult the primary citations listed with each rule.
Why a species-specific page? Metolazone pharmacokinetics differ across species: dose ranges, intervals, and route preferences are not interchangeable. Cross-extrapolation from canine doses is unsafe in dog — the rules above are the citations specific to this species, not generic recommendations.
Sourced from published veterinary references; awaiting credentialed clinical reviewer. See our editorial process. Reference only — not veterinary advice.