Penicillin G for Dog
Dog · Canis lupus familiaris · typical adult weight 2.00–80.00 kg
Penicillin G is used in dog for Gram-positive infections, leptospirosis (procaine). Routes documented in dog: IM. A typical adult dog weighs 2.00–80.00 kg. ExoticRx lists 1 cited dose rule for Penicillin G in dog, drawn from published veterinary references. Verify against current literature before clinical use.
Trade names: Pen-G, Crysticillin
Dose ranges
| Route | Dose | Frequency | Duration | Indication | Evidence | Source |
|---|---|---|---|---|---|---|
| IM | 13.2–26.4 mg/kg | q12-24h | 7-14 days | Gram-positive infections, leptospirosis (procaine) | Strong | Plumb's Veterinary Drug Handbook, 9th Ed |
Need the exact dose for your patient?
These ranges are per kg. Enter your dog's weight to get the precise dose and draw-up volume — unit and concentration math done for you.
Mechanism of action
Inhibits bacterial cell wall synthesis by binding PBPs. Bactericidal. Narrow spectrum: primarily gram-positive and some anaerobes.
Side effects & warnings
CONTRAINDICATED in rabbits, guinea pigs, hamsters. Hypersensitivity reactions. Procaine form: IM/SC only (never IV). Potassium form: slow IV only. Pain at injection site.
Species-specific contraindications and adverse-reaction reports for dog may differ from canine / feline reference data — consult the primary citations listed with each rule.
Other Antibiotic drugs with dog dosing
Penicillin G dosing in other species
Why a species-specific page? Penicillin G pharmacokinetics differ across species: dose ranges, intervals, and route preferences are not interchangeable. Cross-extrapolation from canine doses is unsafe in dog — the rules above are the citations specific to this species, not generic recommendations.
Sourced from published veterinary references; awaiting credentialed clinical reviewer. See our editorial process. Reference only — not veterinary advice.