Dog · Canis lupus familiaris · typical adult weight 2.00–80.00 kg
Propentofylline is dosed at 3–5 mg/kg PO q12h in dogs, per Siwak CT, Gruet P, Woehrlé F et al. (2000). Comparison of the effects of adrafinil, propentofylline, and nicergoline on behavior in aged dogs. American Journal of Veterinary Research 61, 1410-1414 doi:10.2460/ajvr.2000.61.1410 — Verified against BSAVA Small Animal Formulary, 10th Ed, Part A, p.362 (2026-08-01).. Propentofylline is used in dogs for Cognitive dysfunction syndrome, lethargy in geriatric dogs. Routes documented in dogs: PO. A typical adult dog weighs 2.00–80.00 kg. ExoticRx lists 1 cited dose rule for Propentofylline in dogs, drawn from published veterinary references. Verify against current literature before clinical use.
US trade names: Vivitonin, Karsivan
| Route | Dose | Frequency | Duration | Indication | Evidence | Source |
|---|---|---|---|---|---|---|
| PO | 3–5 mg/kg | q12h | Long-term | Cognitive dysfunction syndrome, lethargy in geriatric dogs | Moderate | Siwak CT, Gruet P, Woehrlé F et al. (2000). Comparison of the effects of adrafinil, propentofylline, and nicergoline on behavior in aged dogs. American Journal of Veterinary Research 61, 1410-1414 doi:10.2460/ajvr.2000.61.1410 — Verified against BSAVA Small Animal Formulary, 10th Ed, Part A, p.362 (2026-08-01). |
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These ranges are per kg. Enter your dog's weight to get the precise dose and draw-up volume — unit and concentration math done for you.
Inhibits adenosine reuptake and phosphodiesterase, improving microcirculation and red blood cell deformability. Neuroprotective via adenosine receptor modulation.
Licensed in some countries for canine cognitive dysfunction and lethargy/dullness in old dogs. Give on empty stomach. GI upset rare.
Species-specific contraindications and adverse-reaction reports for dogs may differ from canine / feline reference data — consult the primary citations listed with each rule.
Propentofylline dose range in dogs, with cited source references: PO 3–5 mg/kg q12h. Reference ranges from cited sources — verify against current literature before clinical use.
Documented routes for Propentofylline in dogs: PO.
Cited course lengths for Propentofylline in dogs include: Long-term. Duration depends on the indication — match it to the specific dose rule in the table above.
Propentofylline is indicated in dogs for: Cognitive dysfunction syndrome, lethargy in geriatric dogs.
These are general warnings for Propentofylline across species; consult the dog dosing table above for species-specific guidance. Licensed in some countries for canine cognitive dysfunction and lethargy/dullness in old dogs. Give on empty stomach. GI upset rare.
Why a species-specific page? Propentofylline pharmacokinetics differ across species: dose ranges, intervals, and route preferences are not interchangeable. Cross-extrapolation from canine doses is unsafe in dogs — the rules above are the citations specific to this species, not generic recommendations.
Sourced from published veterinary references; awaiting credentialed clinical reviewer. See our editorial process. Reference only — not veterinary advice.