ExoticRx · exoticrx.com/drugs/propentofylline
US brand names:Vivitonin, Karsivan
Propentofylline is dosed at 3–5 mg/kg PO q12h in dogs, per Siwak CT, Gruet P, Woehrlé F et al. (2000). Comparison of the effects of adrafinil, propentofylline, and nicergoline on behavior in aged dogs. American Journal of Veterinary Research 61, 1410-1414 doi:10.2460/ajvr.2000.61.1410 — Verified against BSAVA Small Animal Formulary, 10th Ed, Part A, p.362 (2026-08-01).. Verify against current literature before clinical use.
Inhibits adenosine reuptake and phosphodiesterase, improving microcirculation and red blood cell deformability. Neuroprotective via adenosine receptor modulation.
Licensed in some countries for canine cognitive dysfunction and lethargy/dullness in old dogs. Give on empty stomach. GI upset rare.
Species references:All Dog (Domestic) drugs
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| Species | Route | Dose | Frequency | Evidence | Source |
|---|---|---|---|---|---|
| Dog (Domestic) | PO | 3–5 mg/kg | q12h | Moderate | Siwak CT, Gruet P, Woehrlé F et al. (2000). Comparison of the effects of adrafinil, propentofylline, and nicergoline on behavior in aged dogs. American Journal of Veterinary Research 61, 1410-1414 doi:10.2460/ajvr.2000.61.1410 — Verified against BSAVA Small Animal Formulary, 10th Ed, Part A, p.362 (2026-08-01). |
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