Dog · Canis lupus familiaris · typical adult weight 2.00–80.00 kg
Propofol is dosed at 4–6 mg/kg IV To effect (titrate IV) in dogs, per Propoflo - Propofol Injection, Emulsion [US Product Label for Dogs]. Zoetis Inc.; 2021. https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=9c7679bd-31d1-4a62-b7b5-d0c52be1fccd — Verified against Plumb's Veterinary Drug Handbook, 10th Ed, p.1111 (2026-08-01). — Plumb's 10th ed (held) printed p.1080, Propofol monograph spanning p.1080-1085; page located 2026-08-05 from the book's own running heads, verified to name the drug in its body text. — SOURCE EDITION: Plumb's Veterinary Drug Handbook — ISBN 9781394172207, https://openlibrary.org/isbn/9781394172207. Propofol is used in dogs for Induction of general anesthesia. Routes documented in dogs: IV. A typical adult dog weighs 2.00–80.00 kg. ExoticRx lists 1 cited dose rule for Propofol in dogs, drawn from published veterinary references. Verify against current literature before clinical use.
US trade names: Rapinovet, PropoFlo
| Route | Dose | Frequency | Duration | Indication | Evidence | Source |
|---|---|---|---|---|---|---|
| IV | 4–6 mg/kg | To effect (titrate IV) | Single induction | Induction of general anesthesia |
| Strong |
| Propoflo - Propofol Injection, Emulsion [US Product Label for Dogs]. Zoetis Inc.; 2021. https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=9c7679bd-31d1-4a62-b7b5-d0c52be1fccd — Verified against Plumb's Veterinary Drug Handbook, 10th Ed, p.1111 (2026-08-01). — Plumb's 10th ed (held) printed p.1080, Propofol monograph spanning p.1080-1085; page located 2026-08-05 from the book's own running heads, verified to name the drug in its body text. — SOURCE EDITION: Plumb's Veterinary Drug Handbook — ISBN 9781394172207, https://openlibrary.org/isbn/9781394172207 |
Every held source for this drug and species, as printed. Where they differ, both are shown — the choice is yours, not ours.
The sources disagree for this combination. The ranges below do not overlap on a comparable route. This is not an error in one of them — published veterinary references differ, and reconciling them for a particular patient is a clinical judgement.
| Dose (%) | Route | Source | As printed |
|---|---|---|---|
| 30 | — | Papich Saunders Handbook of Veterinary Drugs, 4th edp.713 | premedications, lower the dose by 20%-30% (e.g., lower dose of 3 mg/kg can be |
| 20 | — | Papich Saunders Handbook of Veterinary Drugs, 4th edp.713 | premedications, lower the dose by 20%-30% (e.g., lower dose of 3 mg/kg can be |
| Dose (mcg/kg) | Route | Source | As printed |
|---|---|---|---|
| 100–400 |
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Enhances GABA-A receptor activity, producing rapid-onset, ultra-short-acting general anesthesia. Also has some NMDA receptor antagonism.
Respiratory depression/apnea — have intubation equipment ready. No analgesic properties. Hypotension. Repeated use in cats may cause Heinz body formation. Strict aseptic handling (lipid emulsion supports bacterial growth).
Species-specific contraindications and adverse-reaction reports for dogs may differ from canine / feline reference data — consult the primary citations listed with each rule.
Propofol dose range in dogs, with cited source references: IV 4–6 mg/kg To effect (titrate IV). Reference ranges from cited sources — verify against current literature before clinical use.
Documented routes for Propofol in dogs: IV.
Cited course lengths for Propofol in dogs include: Single induction. Duration depends on the indication — match it to the specific dose rule in the table above.
Propofol is indicated in dogs for: Induction of general anesthesia.
These are general warnings for Propofol across species; consult the dog dosing table above for species-specific guidance. Respiratory depression/apnea — have intubation equipment ready. No analgesic properties. Hypotension. Repeated use in cats may cause Heinz body formation. Strict aseptic handling (lipid emulsion supports bacterial growth).
Why a species-specific page? Propofol pharmacokinetics differ across species: dose ranges, intervals, and route preferences are not interchangeable. Cross-extrapolation from canine doses is unsafe in dogs — the rules above are the citations specific to this species, not generic recommendations.
Sourced from published veterinary references; awaiting credentialed clinical reviewer. See our editorial process. Reference only — not veterinary advice.
| IV |
| Papich Saunders Handbook of Veterinary Drugs, 4th edp.713 |
| • CRI: 5 mg/kg slowly IV, followed by 100-400 mcg/kg/min (or 6-24 mg/kg/hour). |
| Dose (mg/kg) | Route | Source | As printed |
|---|---|---|---|
| 6–7 | IV | BSAVA Small Animal Formulary, 10th ed — Part A (Canine and Feline)p.363 | 6-7 mg/kg i.v.; premedicated 1-4 mg/kg i.v. Continuous rate infusion for sedation or maintenance of |
| 1–4 | IV | BSAVA Small Animal Formulary, 10th ed — Part A (Canine and Feline)p.363 | 6-7 mg/kg i.v.; premedicated 1-4 mg/kg i.v. Continuous rate infusion for sedation or maintenance of anaesthesia: 0.1-0.4 mg/kg/m |
| 3 | — | Papich Saunders Handbook of Veterinary Drugs, 4th edp.713 | premedications, lower the dose by 20%-30% (e.g., lower dose of 3 mg/kg can be |
| 1–3 | IV | Papich Saunders Handbook of Veterinary Drugs, 4th edp.713 | used). After initial induction, maintenance doses of 1-3 mg/kg IV can be used. |
| 5 | IV |
Figures are transcribed from the cited page or table of each held edition and are shown for reference only. They are not dose recommendations, they do not feed the calculator, and none has been reviewed by a veterinarian.
| Papich Saunders Handbook of Veterinary Drugs, 4th edp.713 |
| • CRI: 5 mg/kg slowly IV, followed by 100-400 mcg/kg/min (or 6-24 mg/kg/hour). |
| 6–24 | IV | Papich Saunders Handbook of Veterinary Drugs, 4th edp.713 | • CRI: 5 mg/kg slowly IV, followed by 100-400 mcg/kg/min (or 6-24 mg/kg/hour). |
| 1–6 | IV | Papich Saunders Handbook of Veterinary Drugs, 4th edp.713 | • Status epilepticus: 1-6 mg/kg IV (to effect), followed by CRI of 0.1-0.6 mg/ |
| 5–7 | IV | Papich Saunders Handbook of Veterinary Drugs, 4th edp.713 | duction is 5-7 mg/kg IV, most inductions can be performed with 3.7 (61.5) |
| 0.5–1 | — | Papich Saunders Handbook of Veterinary Drugs, 4th edp.713 | given at 0.5-1 mg/kg for intubation. Although the typical range needed for in- |
| 6.6 | IV | Papich Saunders Handbook of Veterinary Drugs, 4th edp.713 | • 6.6 mg/kg IV slowly over 30-60 seconds. If necessary, an additional dose can be |