Dog · Canis lupus familiaris · typical adult weight 2.00–80.00 kg
Sildenafil is dosed at 1–3 mg/kg PO q8h in dogs, per Bach J, Rozanski E, MacGregor J. Retrospective evaluation of sildenafil citrate as a therapy for pulmonary hypertension in dogs. J Vet Intern Med. 2006;20:1132-1135. doi:10.1111/j.1939-1676.2006.tb00711.x — Verified against Plumb's Veterinary Drug Handbook, 10th Ed, p.1187 (2026-08-01). — Plumb's 10th ed (held) printed p.1160, Sildenafil monograph spanning p.1159-1160; page located 2026-08-05 from the book's own running heads, and carries this exact dose under the matching species heading. — SOURCE EDITION: Plumb's Veterinary Drug Handbook — ISBN 9781394172207, https://openlibrary.org/isbn/9781394172207. Sildenafil is used in dogs for Pulmonary hypertension. Routes documented in dogs: PO. A typical adult dog weighs 2.00–80.00 kg. ExoticRx lists 1 cited dose rule for Sildenafil in dogs, drawn from published veterinary references. Verify against current literature before clinical use.
US trade names: Viagra, Revatio
| Route | Dose | Frequency | Duration | Indication | Evidence | Source |
|---|---|---|---|---|---|---|
| PO | 1–3 mg/kg | q8h | Long-term | Pulmonary hypertension | Moderate | Bach J, Rozanski E, MacGregor J. Retrospective evaluation of sildenafil citrate as a therapy for pulmonary hypertension in dogs. J Vet Intern Med. 2006;20:1132-1135. doi:10.1111/j.1939-1676.2006.tb00711.x — Verified against Plumb's Veterinary Drug Handbook, 10th Ed, p.1187 (2026-08-01). — Plumb's 10th ed (held) printed p.1160, Sildenafil monograph spanning p.1159-1160; page located 2026-08-05 from the book's own running heads, and carries this exact dose under the matching species heading. — SOURCE EDITION: Plumb's Veterinary Drug Handbook — ISBN 9781394172207, https://openlibrary.org/isbn/9781394172207 |
Every held source for this drug and species, as printed. Where they differ, both are shown — the choice is yours, not ours.
| Dose (mg/kg) | Route | Source | As printed |
|---|---|---|---|
| 0.5–2.7 | PO | BSAVA Small Animal Formulary, 10th ed — Part A (Canine and Feline)p.391 | 0.5-2.7 mg/kg p.o. q8-24h; suggested median dose from clinical studies in dogs is 3 mg/kg/day. 376 B |
| 2 | PO | Papich Saunders Handbook of Veterinary Drugs, 4th edp.755 | • 2 mg/kg q12h PO. Dose interval may range from 8-24 hours, and doses as high |
| 3 | — | Papich Saunders Handbook of Veterinary Drugs, 4th edp.755 | as 3 mg/kg have been administered to some dogs. |
Figures are transcribed from the cited page or table of each held edition and are shown for reference only. They are not dose recommendations, they do not feed the calculator, and none has been reviewed by a veterinarian.
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Inhibits phosphodiesterase-5, preventing cGMP breakdown in pulmonary vascular smooth muscle, causing pulmonary vasodilation.
Used for pulmonary hypertension in dogs. Hypotension possible. CONTRAINDICATED with nitrates. Monitor systemic blood pressure. Give with or without food.
Species-specific contraindications and adverse-reaction reports for dogs may differ from canine / feline reference data — consult the primary citations listed with each rule.
Sildenafil dose range in dogs, with cited source references: PO 1–3 mg/kg q8h. Reference ranges from cited sources — verify against current literature before clinical use.
Documented routes for Sildenafil in dogs: PO.
Cited course lengths for Sildenafil in dogs include: Long-term. Duration depends on the indication — match it to the specific dose rule in the table above.
Sildenafil is indicated in dogs for: Pulmonary hypertension.
These are general warnings for Sildenafil across species; consult the dog dosing table above for species-specific guidance. Used for pulmonary hypertension in dogs. Hypotension possible. CONTRAINDICATED with nitrates. Monitor systemic blood pressure. Give with or without food.
Why a species-specific page? Sildenafil pharmacokinetics differ across species: dose ranges, intervals, and route preferences are not interchangeable. Cross-extrapolation from canine doses is unsafe in dogs — the rules above are the citations specific to this species, not generic recommendations.
Sourced from published veterinary references; awaiting credentialed clinical reviewer. See our editorial process. Reference only — not veterinary advice.