ExoticRx · exoticrx.com/drugs/streptozocin
Zanosar
Glucosamine-nitrosourea compound selectively taken up by pancreatic beta cells via GLUT2 transporter. Alkylates DNA causing strand breaks. Selective pancreatic islet cell cytotoxicity.
Nephrotoxic — aggressive saline diuresis required. Used specifically for insulinoma in dogs. Monitor renal function, blood glucose. Severe nausea/vomiting.
Species references:All Cat (Domestic) drugsAll Dog (Domestic) drugs
Each ExoticRx dose rule is graded by the strength of its primary evidence — see the editorial process.
A dog/cat sample is shown here. Cited dosing for all 2 species — reptiles, birds, pocket pets, livestock, and equine — is free on the per-species pages above. Pro adds the weight-based calculator for every species.
| Species | Route | Dose | Frequency | Evidence | Source |
|---|---|---|---|---|---|
| Dog (Domestic) | IV | 500 mg/m2 | q3 weeks | Moderate | Withrow & MacEwen's Small Animal Clinical Oncology, 6th Ed |
| Cat (Domestic) | IV | 500 mg/m2 | q3 weeks | Extrapolated | Withrow & MacEwen's Small Animal Clinical Oncology, 6th Ed |
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