ExoticRx · exoticrx.com/drugs/streptozocin
US brand names:Zanosar
Streptozocin is dosed at 500 mg/m2 IV q3 weeks in dogs, per Moore AS, Nelson RW, Henry CJ, et al: Streptozocin for treatment of pancreatic islet cell tumors in dogs: 17 cases (1989-1999), J Am Vet Med Assoc 221:811, 2002. — Verified against Withrow & MacEwen's Small Animal Clinical Oncology, 5th Ed, p.181 (2026-08-01).. Verify against current literature before clinical use.
Glucosamine-nitrosourea compound selectively taken up by pancreatic beta cells via GLUT2 transporter. Alkylates DNA causing strand breaks. Selective pancreatic islet cell cytotoxicity.
Nephrotoxic — aggressive saline diuresis required. Used specifically for insulinoma in dogs. Monitor renal function, blood glucose. Severe nausea/vomiting.
Species references:All Dog (Domestic) drugs
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| Species | Route | Dose | Frequency | Evidence | Source |
|---|---|---|---|---|---|
| Dog (Domestic) | IV | 500 mg/m2 | q3 weeks | Moderate | Moore AS, Nelson RW, Henry CJ, et al: Streptozocin for treatment of pancreatic islet cell tumors in dogs: 17 cases (1989-1999), J Am Vet Med Assoc 221:811, 2002. — Verified against Withrow & MacEwen's Small Animal Clinical Oncology, 5th Ed, p.181 (2026-08-01). |
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