Dog · Canis lupus familiaris · typical adult weight 2.00–80.00 kg
Streptozocin is dosed at 500 mg/m2 IV q3 weeks in dogs, per Moore AS, Nelson RW, Henry CJ, et al: Streptozocin for treatment of pancreatic islet cell tumors in dogs: 17 cases (1989-1999), J Am Vet Med Assoc 221:811, 2002. — Verified against Withrow & MacEwen's Small Animal Clinical Oncology, 5th Ed, p.181 (2026-08-01).. Streptozocin is used in dogs for Metastatic insulinoma. Routes documented in dogs: IV. A typical adult dog weighs 2.00–80.00 kg. ExoticRx lists 1 cited dose rule for Streptozocin in dogs, drawn from published veterinary references. Verify against current literature before clinical use.
US trade names: Zanosar
| Route | Dose | Frequency | Duration | Indication | Evidence | Source |
|---|---|---|---|---|---|---|
| IV | 500 mg/m2 | q3 weeks | Multiple cycles; monitor renal function before each dose | Metastatic insulinoma | Moderate | Moore AS, Nelson RW, Henry CJ, et al: Streptozocin for treatment of pancreatic islet cell tumors in dogs: 17 cases (1989-1999), J Am Vet Med Assoc 221:811, 2002. — Verified against Withrow & MacEwen's Small Animal Clinical Oncology, 5th Ed, p.181 (2026-08-01). |
Need the exact dose for your patient?
Enter your dog's weight to check these cited ranges in the calculator — unit and concentration math done for you.
Glucosamine-nitrosourea compound selectively taken up by pancreatic beta cells via GLUT2 transporter. Alkylates DNA causing strand breaks. Selective pancreatic islet cell cytotoxicity.
Nephrotoxic — aggressive saline diuresis required. Used specifically for insulinoma in dogs. Monitor renal function, blood glucose. Severe nausea/vomiting.
Species-specific contraindications and adverse-reaction reports for dogs may differ from canine / feline reference data — consult the primary citations listed with each rule.
Streptozocin dose range in dogs, with cited source references: IV 500 mg/m2 q3 weeks. Reference ranges from cited sources — verify against current literature before clinical use.
Documented routes for Streptozocin in dogs: IV.
Cited course lengths for Streptozocin in dogs include: Multiple cycles; monitor renal function before each dose. Duration depends on the indication — match it to the specific dose rule in the table above.
Streptozocin is indicated in dogs for: Metastatic insulinoma.
These are general warnings for Streptozocin across species; consult the dog dosing table above for species-specific guidance. Nephrotoxic — aggressive saline diuresis required. Used specifically for insulinoma in dogs. Monitor renal function, blood glucose. Severe nausea/vomiting.
Why a species-specific page? Streptozocin pharmacokinetics differ across species: dose ranges, intervals, and route preferences are not interchangeable. Cross-extrapolation from canine doses is unsafe in dogs — the rules above are the citations specific to this species, not generic recommendations.
Sourced from published veterinary references; awaiting credentialed clinical reviewer. See our editorial process. Reference only — not veterinary advice.