Dog · Canis lupus familiaris · typical adult weight 2.00–80.00 kg
Streptozocin is dosed at 500 mg/m2 IV q3 weeks in dogs, per Moore AS, Nelson RW, Henry CJ, et al: Streptozocin for treatment of pancreatic islet cell tumors in dogs: 17 cases (1989-1999), J Am Vet Med Assoc 221:811, 2002. — Verified against Withrow & MacEwen's Small Animal Clinical Oncology, 5th Ed, p.181 (2026-08-01). — SOURCE EDITION: Withrow and MacEwen's Small Animal Clinical Oncology — ISBN 9781437723625, https://openlibrary.org/isbn/9781437723625. Streptozocin is used in dogs for Metastatic insulinoma. Routes documented in dogs: IV. A typical adult dog weighs 2.00–80.00 kg. ExoticRx lists 1 cited dose rule for Streptozocin in dogs, drawn from published veterinary references. Verify against current literature before clinical use.
US trade names: Zanosar
| Route | Dose | Frequency | Duration | Indication | Evidence | Source |
|---|---|---|---|---|---|---|
| IV | 500 mg/m2 | q3 weeks | Multiple cycles; monitor renal function before each dose | Metastatic insulinoma | Moderate | Moore AS, Nelson RW, Henry CJ, et al: Streptozocin for treatment of pancreatic islet cell tumors in dogs: 17 cases (1989-1999), J Am Vet Med Assoc 221:811, 2002. — Verified against Withrow & MacEwen's Small Animal Clinical Oncology, 5th Ed, p.181 (2026-08-01). — SOURCE EDITION: Withrow and MacEwen's Small Animal Clinical Oncology — ISBN 9781437723625, https://openlibrary.org/isbn/9781437723625 |
Every held source for this drug and species, as printed. Where they differ, both are shown — the choice is yours, not ours.
| Dose (mg/m2) | Route | Source | As printed |
|---|---|---|---|
| 500 | IV | Papich Saunders Handbook of Veterinary Drugs, 4th edp.771 | • 500 mg/m2 IV infused over 2 hours every 3 weeks (use with a saline diuresis). |
Figures are transcribed from the cited page or table of each held edition and are shown for reference only. They are not dose recommendations, they do not feed the calculator, and none has been reviewed by a veterinarian.
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Glucosamine-nitrosourea compound selectively taken up by pancreatic beta cells via GLUT2 transporter. Alkylates DNA causing strand breaks. Selective pancreatic islet cell cytotoxicity.
Nephrotoxic — aggressive saline diuresis required. Used specifically for insulinoma in dogs. Monitor renal function, blood glucose. Severe nausea/vomiting.
Species-specific contraindications and adverse-reaction reports for dogs may differ from canine / feline reference data — consult the primary citations listed with each rule.
Streptozocin dose range in dogs, with cited source references: IV 500 mg/m2 q3 weeks. Reference ranges from cited sources — verify against current literature before clinical use.
Documented routes for Streptozocin in dogs: IV.
Cited course lengths for Streptozocin in dogs include: Multiple cycles; monitor renal function before each dose. Duration depends on the indication — match it to the specific dose rule in the table above.
Streptozocin is indicated in dogs for: Metastatic insulinoma.
These are general warnings for Streptozocin across species; consult the dog dosing table above for species-specific guidance. Nephrotoxic — aggressive saline diuresis required. Used specifically for insulinoma in dogs. Monitor renal function, blood glucose. Severe nausea/vomiting.
Why a species-specific page? Streptozocin pharmacokinetics differ across species: dose ranges, intervals, and route preferences are not interchangeable. Cross-extrapolation from canine doses is unsafe in dogs — the rules above are the citations specific to this species, not generic recommendations.
Sourced from published veterinary references; awaiting credentialed clinical reviewer. See our editorial process. Reference only — not veterinary advice.