Dog · Canis lupus familiaris · typical adult weight 2.00–80.00 kg
Streptozocin is used in dog for Metastatic insulinoma, Insulinoma, Glucagonoma / APUDomas. Routes documented in dog: IV. A typical adult dog weighs 2.00–80.00 kg. ExoticRx lists 3 cited dose rules for Streptozocin in dog, drawn from published veterinary references. Verify against current literature before clinical use.
Trade names: Zanosar
| Route | Dose | Frequency | Duration | Indication | Evidence | Source |
|---|---|---|---|---|---|---|
| IV | 500 mg/m2 | q3 weeks | Multiple cycles; monitor renal function before each dose | Metastatic insulinoma | Moderate | Withrow & MacEwen's Small Animal Clinical Oncology, 6th Ed |
| IV | 500 mg/kg | IV with saline diuresis q14-21 days | Must pre- and post-hydrate with saline | Insulinoma | Moderate | Withrow & MacEwen's Small Animal Clinical Oncology, 6th Ed |
| IV | 500 mg/kg | 500mg/m2 IV with saline diuresis q21 days | Monitor renal function at each cycle | Glucagonoma / APUDomas | Weak | Withrow & MacEwen's Small Animal Clinical Oncology, 6th Ed |
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These ranges are per kg. Enter your dog's weight to get the precise dose and draw-up volume — unit and concentration math done for you.
Glucosamine-nitrosourea compound selectively taken up by pancreatic beta cells via GLUT2 transporter. Alkylates DNA causing strand breaks. Selective pancreatic islet cell cytotoxicity.
Nephrotoxic — aggressive saline diuresis required. Used specifically for insulinoma in dogs. Monitor renal function, blood glucose. Severe nausea/vomiting.
Species-specific contraindications and adverse-reaction reports for dog may differ from canine / feline reference data — consult the primary citations listed with each rule.
Why a species-specific page? Streptozocin pharmacokinetics differ across species: dose ranges, intervals, and route preferences are not interchangeable. Cross-extrapolation from canine doses is unsafe in dog — the rules above are the citations specific to this species, not generic recommendations.
Sourced from published veterinary references; awaiting credentialed clinical reviewer. See our editorial process. Reference only — not veterinary advice.