ExoticRx · exoticrx.com/drugs/tigilanol-tiglate
US brand names:Stelfonta
Tigilanol Tiglate is dosed at Dosing: 0.5 mg/cm3 tumor volume in dogs, per Stelfonta(R) [tigilanol tiglate] US prescribing information. Fort Worth, TX: Virbac AH; 2020. — Verified against Plumb's Veterinary Drug Handbook, 10th Ed, p.1260 (2026-08-01).. Verify against current literature before clinical use.
Activates protein kinase C, disrupting tumor vasculature and causing hemorrhagic necrosis. Also stimulates innate immune response against tumor cells.
Dogs only. For non-metastatic mast cell tumors (cutaneous/SC). Wound at injection site expected — heals by second intention. Sedation/anesthesia required for injection.
Species references:All Dog (Domestic) drugs
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| Species | Route | Dose | Frequency | Evidence | Source |
|---|---|---|---|---|---|
| Dog (Domestic) | INTRATUMORAL | Dosing: 0.5 mg/cm3 tumor volume | Single treatment; may repeat once at day 28 | Strong | Stelfonta(R) [tigilanol tiglate] US prescribing information. Fort Worth, TX: Virbac AH; 2020. — Verified against Plumb's Veterinary Drug Handbook, 10th Ed, p.1260 (2026-08-01). |
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