ExoticRx · exoticrx.com/drugs/toceranib
US brand names:Palladia, Palladia Oral Solution, Palladia (Toceranib Phosphate Solution)
Toceranib is dosed at 2.5–3.25 mg/kg PO q48h (every other day) in dogs, per PALLADIA - Toceranib Phosphate Tablet [US Product Label for Dogs]. Zoetis Inc.; 2018. https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=ae09ae83-0812-4ddc-92e3-730f7a1ae449 — Verified against Plumb's Veterinary Drug Handbook, 10th Ed, p.1278 (2026-08-01).. Verify against current literature before clinical use.
Multi-target TKI inhibiting c-Kit, VEGFR2, PDGFR-beta, and other kinases. Anti-tumor and anti-angiogenic activity.
FDA-approved for canine mast cell tumors (Palladia). GI toxicity, neutropenia, GI perforation, hypertension. Monitor CBC, blood pressure, urinalysis. Every-other-day dosing.
Species references:All Dog (Domestic) drugs
Each ExoticRx dose rule is graded by the strength of its primary evidence — see the editorial process.
A dog/cat sample is shown here. Cited dosing for all 1 species — reptiles, birds, pocket pets, livestock, and equine — is free on the per-species pages above. Pro adds the weight-based calculator for every species.
| Species | Route | Dose | Frequency | Evidence | Source |
|---|---|---|---|---|---|
| Dog (Domestic) | PO | 2.5–3.25 mg/kg | q48h (every other day) | Strong | PALLADIA - Toceranib Phosphate Tablet [US Product Label for Dogs]. Zoetis Inc.; 2018. https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=ae09ae83-0812-4ddc-92e3-730f7a1ae449 — Verified against Plumb's Veterinary Drug Handbook, 10th Ed, p.1278 (2026-08-01). |
| Dog (Domestic) | PO | 2.5–3.25 mg/kg | q48h (every other day) | Moderate | PALLADIA - Toceranib Phosphate Tablet [US Product Label for Dogs]. Zoetis Inc.; 2018. https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=ae09ae83-0812-4ddc-92e3-730f7a1ae449 — Verified against Plumb's Veterinary Drug Handbook, 10th Ed, p.1278 (2026-08-01). |
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View PlansSource citations and evidence levels available on the live page. Reference only — verify against current literature before clinical use.