Dog · Canis lupus familiaris · typical adult weight 2.00–80.00 kg
Toceranib is dosed at 2.5–3.25 mg/kg PO q48h (every other day) in dogs, per PALLADIA - Toceranib Phosphate Tablet [US Product Label for Dogs]. Zoetis Inc.; 2018. https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=ae09ae83-0812-4ddc-92e3-730f7a1ae449 — Verified against Plumb's Veterinary Drug Handbook, 10th Ed, p.1278 (2026-08-01).. Toceranib is used in dogs for Mast cell tumors, Mast cell tumors, various carcinomas. Routes documented in dogs: PO. A typical adult dog weighs 2.00–80.00 kg. ExoticRx lists 2 cited dose rules for Toceranib in dogs, drawn from published veterinary references. Verify against current literature before clinical use.
US trade names: Palladia, Palladia Oral Solution, Palladia (Toceranib Phosphate Solution)
| Route | Dose | Frequency | Duration | Indication | Evidence | Source |
|---|---|---|---|---|---|---|
| PO | 2.5–3.25 mg/kg | q48h (every other day) | Long-term | Mast cell tumors | Strong | PALLADIA - Toceranib Phosphate Tablet [US Product Label for Dogs]. Zoetis Inc.; 2018. https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=ae09ae83-0812-4ddc-92e3-730f7a1ae449 — Verified against Plumb's Veterinary Drug Handbook, 10th Ed, p.1278 (2026-08-01). |
| PO | 2.5–3.25 mg/kg | q48h (every other day) | Until progression or intolerance | Mast cell tumors, various carcinomas | Moderate | PALLADIA - Toceranib Phosphate Tablet [US Product Label for Dogs]. Zoetis Inc.; 2018. https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=ae09ae83-0812-4ddc-92e3-730f7a1ae449 — Verified against Plumb's Veterinary Drug Handbook, 10th Ed, p.1278 (2026-08-01). |
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These ranges are per kg. Enter your dog's weight to get the precise dose and draw-up volume — unit and concentration math done for you.
Multi-target TKI inhibiting c-Kit, VEGFR2, PDGFR-beta, and other kinases. Anti-tumor and anti-angiogenic activity.
FDA-approved for canine mast cell tumors (Palladia). GI toxicity, neutropenia, GI perforation, hypertension. Monitor CBC, blood pressure, urinalysis. Every-other-day dosing.
Species-specific contraindications and adverse-reaction reports for dogs may differ from canine / feline reference data — consult the primary citations listed with each rule.
Toceranib dose ranges in dogs, with cited source references: PO 2.5–3.25 mg/kg q48h (every other day); PO 2.5–3.25 mg/kg q48h (every other day). Reference ranges from cited sources — verify against current literature before clinical use.
Documented routes for Toceranib in dogs: PO.
Cited course lengths for Toceranib in dogs include: Long-term; Until progression or intolerance. Duration depends on the indication — match it to the specific dose rule in the table above.
Toceranib is indicated in dogs for: Mast cell tumors, Mast cell tumors, various carcinomas.
These are general warnings for Toceranib across species; consult the dog dosing table above for species-specific guidance. FDA-approved for canine mast cell tumors (Palladia). GI toxicity, neutropenia, GI perforation, hypertension. Monitor CBC, blood pressure, urinalysis. Every-other-day dosing.
Why a species-specific page? Toceranib pharmacokinetics differ across species: dose ranges, intervals, and route preferences are not interchangeable. Cross-extrapolation from canine doses is unsafe in dogs — the rules above are the citations specific to this species, not generic recommendations.
Sourced from published veterinary references; awaiting credentialed clinical reviewer. See our editorial process. Reference only — not veterinary advice.