Dog · Canis lupus familiaris · typical adult weight 2.00–80.00 kg
Toceranib is dosed at 2.5–3.25 mg/kg PO q48h (every other day) in dogs, per PALLADIA - Toceranib Phosphate Tablet [US Product Label for Dogs]. Zoetis Inc.; 2018. https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=ae09ae83-0812-4ddc-92e3-730f7a1ae449 — Verified against Plumb's Veterinary Drug Handbook, 10th Ed, p.1278 (2026-08-01). — Plumb's 10th ed (held) printed p.1249, Toceranib monograph spanning p.1249-1251; page located 2026-08-05 from the book's own running heads, verified to name the drug in its body text. — SOURCE EDITION: Plumb's Veterinary Drug Handbook — ISBN 9781394172207, https://openlibrary.org/isbn/9781394172207. Toceranib is used in dogs for Mast cell tumors, various carcinomas, Mast cell tumors. Routes documented in dogs: PO. A typical adult dog weighs 2.00–80.00 kg. ExoticRx lists 2 cited dose rules for Toceranib in dogs, drawn from published veterinary references. Verify against current literature before clinical use.
US trade names: Palladia, Palladia Oral Solution, Palladia (Toceranib Phosphate Solution)
| Route | Dose | Frequency | Duration | Indication | Evidence | Source |
|---|---|---|---|---|---|---|
| PO | 2.5–3.25 mg/kg | q48h (every other day) | Until progression or intolerance |
| Mast cell tumors, various carcinomas |
| Moderate |
| PALLADIA - Toceranib Phosphate Tablet [US Product Label for Dogs]. Zoetis Inc.; 2018. https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=ae09ae83-0812-4ddc-92e3-730f7a1ae449 — Verified against Plumb's Veterinary Drug Handbook, 10th Ed, p.1278 (2026-08-01). — Plumb's 10th ed (held) printed p.1249, Toceranib monograph spanning p.1249-1251; page located 2026-08-05 from the book's own running heads, verified to name the drug in its body text. — SOURCE EDITION: Plumb's Veterinary Drug Handbook — ISBN 9781394172207, https://openlibrary.org/isbn/9781394172207 |
| PO | 2.5–3.25 mg/kg | q48h (every other day) | Long-term | Mast cell tumors | Strong | PALLADIA - Toceranib Phosphate Tablet [US Product Label for Dogs]. Zoetis Inc.; 2018. https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=ae09ae83-0812-4ddc-92e3-730f7a1ae449 — Verified against Plumb's Veterinary Drug Handbook, 10th Ed, p.1278 (2026-08-01). — Plumb's 10th ed (held) printed p.1249, Toceranib monograph spanning p.1249-1251; page located 2026-08-05 from the book's own running heads, verified to name the drug in its body text. — SOURCE EDITION: Plumb's Veterinary Drug Handbook — ISBN 9781394172207, https://openlibrary.org/isbn/9781394172207 |
Every held source for this drug and species, as printed. Where they differ, both are shown — the choice is yours, not ours.
| Dose (mg/kg) | Route | Source | As printed |
|---|---|---|---|
| 2.5–3.25 | PO | BSAVA Small Animal Formulary, 10th ed — Part A (Canine and Feline)p.422 | 2.5-3.25 mg/kg p.o. q48h or on a Monday, Wednesday, Friday basis |
| 3.25 | PO | Papich Saunders Handbook of Veterinary Drugs, 4th edp.827 | • 3.25 mg/kg PO every other day. Medical oncologists may recommend a lower |
| 2.5–3 | — | Papich Saunders Handbook of Veterinary Drugs, 4th edp.827 | dosage of 2.5-3 mg/kg per dose and treat on a schedule of 3 days per week |
| 2.2 | — | Papich Saunders Handbook of Veterinary Drugs, 4th edp.827 | 2.2 mg/kg every other day. If adverse reactions occur, discontinue the drug (for |
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These ranges are per kg. Enter your dog's weight to get the precise dose and draw-up volume — unit and concentration math done for you.
Multi-target TKI inhibiting c-Kit, VEGFR2, PDGFR-beta, and other kinases. Anti-tumor and anti-angiogenic activity.
FDA-approved for canine mast cell tumors (Palladia). GI toxicity, neutropenia, GI perforation, hypertension. Monitor CBC, blood pressure, urinalysis. Every-other-day dosing.
Species-specific contraindications and adverse-reaction reports for dogs may differ from canine / feline reference data — consult the primary citations listed with each rule.
Toceranib dose ranges in dogs, with cited source references: PO 2.5–3.25 mg/kg q48h (every other day); PO 2.5–3.25 mg/kg q48h (every other day). Reference ranges from cited sources — verify against current literature before clinical use.
Documented routes for Toceranib in dogs: PO.
Cited course lengths for Toceranib in dogs include: Until progression or intolerance; Long-term. Duration depends on the indication — match it to the specific dose rule in the table above.
Toceranib is indicated in dogs for: Mast cell tumors, various carcinomas, Mast cell tumors.
These are general warnings for Toceranib across species; consult the dog dosing table above for species-specific guidance. FDA-approved for canine mast cell tumors (Palladia). GI toxicity, neutropenia, GI perforation, hypertension. Monitor CBC, blood pressure, urinalysis. Every-other-day dosing.
Why a species-specific page? Toceranib pharmacokinetics differ across species: dose ranges, intervals, and route preferences are not interchangeable. Cross-extrapolation from canine doses is unsafe in dogs — the rules above are the citations specific to this species, not generic recommendations.
Sourced from published veterinary references; awaiting credentialed clinical reviewer. See our editorial process. Reference only — not veterinary advice.
Figures are transcribed from the cited page or table of each held edition and are shown for reference only. They are not dose recommendations, they do not feed the calculator, and none has been reviewed by a veterinarian.