Dog · Canis lupus familiaris · typical adult weight 2.00–80.00 kg
Zileuton is dosed at 5–15 mg/kg PO q12h in dogs, per Source not established. The citation previously shown here named no retrievable document; a literature search on 2026-07-31 found no source that states this dose for this species and route. Treat as unverified and confirm against a primary reference before clinical use.. Zileuton is used in dogs for Chronic bronchitis (adjunct). Routes documented in dogs: PO. A typical adult dog weighs 2.00–80.00 kg. ExoticRx lists 1 cited dose rule for Zileuton in dogs, drawn from published veterinary references. Verify against current literature before clinical use.
US trade names: Zyflo
| Route | Dose | Frequency | Duration | Indication | Evidence | Source |
|---|---|---|---|---|---|---|
| PO | 5–15 mg/kg | q12h | Investigational; monitor liver enzymes | Chronic bronchitis (adjunct) | Weak | Source not established. The citation previously shown here named no retrievable document; a literature search on 2026-07-31 found no source that states this dose for this species and route. Treat as unverified and confirm against a primary reference before clinical use. |
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These ranges are per kg. Enter your dog's weight to get the precise dose and draw-up volume — unit and concentration math done for you.
Inhibits 5-lipoxygenase enzyme, blocking synthesis of leukotrienes (LTB4, LTC4, LTD4, LTE4) from arachidonic acid, reducing airway inflammation.
Hepatotoxicity risk — monitor ALT. Multiple daily dosing needed. Limited veterinary data. Theoretical benefit in feline asthma.
Species-specific contraindications and adverse-reaction reports for dogs may differ from canine / feline reference data — consult the primary citations listed with each rule.
Zileuton dose range in dogs, with cited source references: PO 5–15 mg/kg q12h. Reference ranges from cited sources — verify against current literature before clinical use.
Documented routes for Zileuton in dogs: PO.
Cited course lengths for Zileuton in dogs include: Investigational; monitor liver enzymes. Duration depends on the indication — match it to the specific dose rule in the table above.
Zileuton is indicated in dogs for: Chronic bronchitis (adjunct).
These are general warnings for Zileuton across species; consult the dog dosing table above for species-specific guidance. Hepatotoxicity risk — monitor ALT. Multiple daily dosing needed. Limited veterinary data. Theoretical benefit in feline asthma.
Why a species-specific page? Zileuton pharmacokinetics differ across species: dose ranges, intervals, and route preferences are not interchangeable. Cross-extrapolation from canine doses is unsafe in dogs — the rules above are the citations specific to this species, not generic recommendations.
Sourced from published veterinary references; awaiting credentialed clinical reviewer. See our editorial process. Reference only — not veterinary advice.