Dog · Canis lupus familiaris · typical adult weight 2.00–80.00 kg
Zileuton is used in dog for Chronic bronchitis (adjunct). Routes documented in dog: PO. A typical adult dog weighs 2.00–80.00 kg. ExoticRx lists 1 cited dose rule for Zileuton in dog, drawn from published veterinary references. Verify against current literature before clinical use.
Trade names: Zyflo
| Route | Dose | Frequency | Duration | Indication | Evidence | Source |
|---|---|---|---|---|---|---|
| PO | 5–15 mg/kg | q12h | Investigational; monitor liver enzymes | Chronic bronchitis (adjunct) | Weak | Veterinary Pulmonology Literature Review |
Need the exact dose for your patient?
These ranges are per kg. Enter your dog's weight to get the precise dose and draw-up volume — unit and concentration math done for you.
Inhibits 5-lipoxygenase enzyme, blocking synthesis of leukotrienes (LTB4, LTC4, LTD4, LTE4) from arachidonic acid, reducing airway inflammation.
Hepatotoxicity risk — monitor ALT. Multiple daily dosing needed. Limited veterinary data. Theoretical benefit in feline asthma.
Species-specific contraindications and adverse-reaction reports for dog may differ from canine / feline reference data — consult the primary citations listed with each rule.
Why a species-specific page? Zileuton pharmacokinetics differ across species: dose ranges, intervals, and route preferences are not interchangeable. Cross-extrapolation from canine doses is unsafe in dog — the rules above are the citations specific to this species, not generic recommendations.
Sourced from published veterinary references; awaiting credentialed clinical reviewer. See our editorial process. Reference only — not veterinary advice.