ExoticRx · exoticrx.com/drugs/loperamide
US brand names:Imodium
Loperamide is dosed at 0.1–0.2 mg/kg PO q8-12h in dogs, per Verified against Plumb's Veterinary Drug Handbook, 10th Ed, p.803 (2026-08-01).. Verify against current literature before clinical use.
Mu-opioid receptor agonist in GI tract, slowing motility and increasing segmental contractions. Increases fluid/electrolyte absorption.
CONTRAINDICATED in MDR1-mutant dogs (crosses BBB — severe CNS depression). Avoid in cats. Do not use in infectious diarrhea. May cause constipation, bloating, ileus.
Species references:All Dog (Domestic) drugs
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