Dog · Canis lupus familiaris · typical adult weight 2.00–80.00 kg
Procarbazine is used in dog for Lymphoma (MOPP protocol component). Routes documented in dog: PO. A typical adult dog weighs 2.00–80.00 kg. ExoticRx lists 1 cited dose rule for Procarbazine in dog, drawn from published veterinary references. Verify against current literature before clinical use.
Trade names: Matulane
| Route | Dose | Frequency | Duration | Indication | Evidence | Source |
|---|---|---|---|---|---|---|
| PO | 50 mg/kg | 50mg/m2 PO q24h x 14 days per cycle | Part of MOPP or LOPP protocol | Lymphoma (MOPP protocol component) | Moderate | Withrow & MacEwen's Small Animal Clinical Oncology, 6th Ed |
Need the exact dose for your patient?
These ranges are per kg. Enter your dog's weight to get the precise dose and draw-up volume — unit and concentration math done for you.
Prodrug that auto-oxidizes to generate reactive species that methylate DNA, causing strand breaks. Also inhibits DNA, RNA, and protein synthesis. Crosses blood-brain barrier.
MAO inhibitor — dietary tyramine interactions (cheese, aged foods). Myelosuppression. GI toxicity. Crosses BBB — used in MOPP-like protocols for CNS lymphoma in dogs.
Species-specific contraindications and adverse-reaction reports for dog may differ from canine / feline reference data — consult the primary citations listed with each rule.
Why a species-specific page? Procarbazine pharmacokinetics differ across species: dose ranges, intervals, and route preferences are not interchangeable. Cross-extrapolation from canine doses is unsafe in dog — the rules above are the citations specific to this species, not generic recommendations.
Sourced from published veterinary references; awaiting credentialed clinical reviewer. See our editorial process. Reference only — not veterinary advice.