Dog · Canis lupus familiaris · typical adult weight 2.00–80.00 kg
Sorafenib is used in dog for Hepatocellular carcinoma (investigational), Thyroid carcinoma (investigational). Routes documented in dog: PO. A typical adult dog weighs 2.00–80.00 kg. ExoticRx lists 2 cited dose rules for Sorafenib in dog, drawn from published veterinary references. Verify against current literature before clinical use.
Trade names: Nexavar
| Route | Dose | Frequency | Duration | Indication | Evidence | Source |
|---|---|---|---|---|---|---|
| PO | 3–5 mg/kg | PO q24h | Chronic use until progression or intolerance | Hepatocellular carcinoma (investigational) | Anecdotal | Withrow & MacEwen's Small Animal Clinical Oncology, 6th Ed |
| PO | 3–5 mg/kg | PO q24h | Until progression | Thyroid carcinoma (investigational) | Anecdotal | Withrow & MacEwen's Small Animal Clinical Oncology, 6th Ed |
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These ranges are per kg. Enter your dog's weight to get the precise dose and draw-up volume — unit and concentration math done for you.
Inhibits multiple kinases including RAF, VEGFR-2/3, PDGFR-beta, c-KIT, FLT-3, and RET. Anti-proliferative and anti-angiogenic dual mechanism.
Hand-foot skin reaction not applicable to veterinary patients but GI toxicity and hepatotoxicity occur. Monitor liver enzymes and weight. Used investigationally for hepatocellular carcinoma.
Species-specific contraindications and adverse-reaction reports for dog may differ from canine / feline reference data — consult the primary citations listed with each rule.
Why a species-specific page? Sorafenib pharmacokinetics differ across species: dose ranges, intervals, and route preferences are not interchangeable. Cross-extrapolation from canine doses is unsafe in dog — the rules above are the citations specific to this species, not generic recommendations.
Sourced from published veterinary references; awaiting credentialed clinical reviewer. See our editorial process. Reference only — not veterinary advice.