Dog · Canis lupus familiaris · typical adult weight 2.00–80.00 kg
Valproic Acid is dosed at 25–60 mg/kg PO q8h in dogs, per Plumb's Veterinary Drug Handbook, 9th Ed. Valproic Acid is used in dogs for Seizures (adjunctive, investigational). Routes documented in dogs: PO. A typical adult dog weighs 2.00–80.00 kg. ExoticRx lists 1 cited dose rule for Valproic Acid in dogs, drawn from published veterinary references. Verify against current literature before clinical use.
US trade names: Depakene, Depakote
| Route | Dose | Frequency | Duration | Indication | Evidence | Source |
|---|---|---|---|---|---|---|
| PO | 25–60 mg/kg | q8h | Long-term | Seizures (adjunctive, investigational) | Weak | Plumb's Veterinary Drug Handbook, 9th Ed |
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These ranges are per kg. Enter your dog's weight to get the precise dose and draw-up volume — unit and concentration math done for you.
Increases GABA levels by inhibiting GABA transaminase and blocking voltage-gated sodium channels. Broad-spectrum anticonvulsant.
Rapidly metabolized in dogs (very short half-life, impractical for chronic use). Hepatotoxic. Teratogenic. May cause thrombocytopenia. Limited use in veterinary medicine.
Species-specific contraindications and adverse-reaction reports for dogs may differ from canine / feline reference data — consult the primary citations listed with each rule.
Valproic Acid dose range in dogs, with cited source references: PO 25–60 mg/kg q8h. Reference ranges from cited sources — verify against current literature before clinical use.
Documented routes for Valproic Acid in dogs: PO.
Cited course lengths for Valproic Acid in dogs include: Long-term. Duration depends on the indication — match it to the specific dose rule in the table above.
Valproic Acid is indicated in dogs for: Seizures (adjunctive, investigational).
These are general warnings for Valproic Acid across species; consult the dog dosing table above for species-specific guidance. Rapidly metabolized in dogs (very short half-life, impractical for chronic use). Hepatotoxic. Teratogenic. May cause thrombocytopenia. Limited use in veterinary medicine.
Why a species-specific page? Valproic Acid pharmacokinetics differ across species: dose ranges, intervals, and route preferences are not interchangeable. Cross-extrapolation from canine doses is unsafe in dogs — the rules above are the citations specific to this species, not generic recommendations.
Sourced from published veterinary references; awaiting credentialed clinical reviewer. See our editorial process. Reference only — not veterinary advice.