ExoticRx · exoticrx.com/drugs/vincristine
US brand names:Oncovin
Vincristine is dosed at 0.5–0.7 mg/m2 IV Weekly per protocol in dogs, per *References 1, 2, 11-13, 42, 51-55. — 1. Rogers KS: Transmissible venereal tumor, Compend Contin Educ Pract Vet 19:1036-1045, 1997. / 2. Das U, Das AK: Review of canine transmissible venereal sarcoma, Vet Res Comm 24:545-556, 2000. — Verified against Withrow & MacEwen's Small Animal Clinical Oncology, 5th Ed, p.708 (2026-08-01).. Verify against current literature before clinical use.
Binds tubulin, inhibiting microtubule assembly and arresting cell division at metaphase. Also stimulates platelet release from megakaryocytes.
VESICANT — perivascular extravasation causes severe tissue necrosis. Administer only IV (never IM or SC). Myelosuppression (nadir 4-7 days). Peripheral neuropathy. Also used to treat immune-mediated thrombocytopenia (platelet stimulation).
Species references:All Cat (Domestic) drugsAll Dog (Domestic) drugs
Each ExoticRx dose rule is graded by the strength of its primary evidence — see the editorial process.
A dog/cat sample is shown here. Cited dosing for all 2 species — reptiles, birds, pocket pets, livestock, and equine — is free on the per-species pages above. Pro adds the weight-based calculator for every species.
| Species | Route | Dose | Frequency | Evidence | Source |
|---|---|---|---|---|---|
| Dog (Domestic) | IV | 0.5–0.7 mg/m2 | Weekly per protocol | Strong | *References 1, 2, 11-13, 42, 51-55. — 1. Rogers KS: Transmissible venereal tumor, Compend Contin Educ Pract Vet 19:1036-1045, 1997. / 2. Das U, Das AK: Review of canine transmissible venereal sarcoma, Vet Res Comm 24:545-556, 2000. — Verified against Withrow & MacEwen's Small Animal Clinical Oncology, 5th Ed, p.708 (2026-08-01). |
| Cat (Domestic) | IV | 0.5 mg/m2 | Weekly per protocol | Moderate | Verified against Plumb's Veterinary Drug Handbook, 10th Ed, p.1333 (2026-08-01). |
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View PlansSource citations and evidence levels available on the live page. Reference only — verify against current literature before clinical use.