Dog · Canis lupus familiaris · typical adult weight 2.00–80.00 kg
Vincristine is dosed at 0.5–0.7 mg/m2 IV Weekly per protocol in dogs, per *References 1, 2, 11-13, 42, 51-55. — 1. Rogers KS: Transmissible venereal tumor, Compend Contin Educ Pract Vet 19:1036-1045, 1997. / 2. Das U, Das AK: Review of canine transmissible venereal sarcoma, Vet Res Comm 24:545-556, 2000. — Verified against Withrow & MacEwen's Small Animal Clinical Oncology, 5th Ed, p.708 (2026-08-01).. Vincristine is used in dogs for Lymphoma (CHOP protocol), immune-mediated thrombocytopenia. Routes documented in dogs: IV. A typical adult dog weighs 2.00–80.00 kg. ExoticRx lists 1 cited dose rule for Vincristine in dogs, drawn from published veterinary references. Verify against current literature before clinical use.
US trade names: Oncovin
| Route | Dose | Frequency | Duration | Indication | Evidence | Source |
|---|---|---|---|---|---|---|
| IV | 0.5–0.7 mg/m2 | Weekly per protocol | Per chemotherapy protocol | Lymphoma (CHOP protocol), immune-mediated thrombocytopenia | Strong | *References 1, 2, 11-13, 42, 51-55. — 1. Rogers KS: Transmissible venereal tumor, Compend Contin Educ Pract Vet 19:1036-1045, 1997. / 2. Das U, Das AK: Review of canine transmissible venereal sarcoma, Vet Res Comm 24:545-556, 2000. — Verified against Withrow & MacEwen's Small Animal Clinical Oncology, 5th Ed, p.708 (2026-08-01). |
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Binds tubulin, inhibiting microtubule assembly and arresting cell division at metaphase. Also stimulates platelet release from megakaryocytes.
VESICANT — perivascular extravasation causes severe tissue necrosis. Administer only IV (never IM or SC). Myelosuppression (nadir 4-7 days). Peripheral neuropathy. Also used to treat immune-mediated thrombocytopenia (platelet stimulation).
Species-specific contraindications and adverse-reaction reports for dogs may differ from canine / feline reference data — consult the primary citations listed with each rule.
Vincristine dose range in dogs, with cited source references: IV 0.5–0.7 mg/m2 Weekly per protocol. Reference ranges from cited sources — verify against current literature before clinical use.
Documented routes for Vincristine in dogs: IV.
Cited course lengths for Vincristine in dogs include: Per chemotherapy protocol. Duration depends on the indication — match it to the specific dose rule in the table above.
Vincristine is indicated in dogs for: Lymphoma (CHOP protocol), immune-mediated thrombocytopenia.
These are general warnings for Vincristine across species; consult the dog dosing table above for species-specific guidance. VESICANT — perivascular extravasation causes severe tissue necrosis. Administer only IV (never IM or SC). Myelosuppression (nadir 4-7 days). Peripheral neuropathy. Also used to treat immune-mediated thrombocytopenia (platelet stimulation).
Why a species-specific page? Vincristine pharmacokinetics differ across species: dose ranges, intervals, and route preferences are not interchangeable. Cross-extrapolation from canine doses is unsafe in dogs — the rules above are the citations specific to this species, not generic recommendations.
Sourced from published veterinary references; awaiting credentialed clinical reviewer. See our editorial process. Reference only — not veterinary advice.