Dog · Canis lupus familiaris · typical adult weight 2.00–80.00 kg
Vincristine is used in dog for Lymphoma (CHOP protocol), immune-mediated thrombocytopenia. Routes documented in dog: IV. A typical adult dog weighs 2.00–80.00 kg. ExoticRx lists 1 cited dose rule for Vincristine in dog, drawn from published veterinary references. Verify against current literature before clinical use.
Trade names: Oncovin
| Route | Dose | Frequency | Duration | Indication | Evidence | Source |
|---|---|---|---|---|---|---|
| IV | 0.5–0.7 mg/m2 | Weekly per protocol | Per chemotherapy protocol | Lymphoma (CHOP protocol), immune-mediated thrombocytopenia | Strong | Plumb's Veterinary Drug Handbook, 9th Ed |
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These ranges are per kg. Enter your dog's weight to get the precise dose and draw-up volume — unit and concentration math done for you.
Binds tubulin, inhibiting microtubule assembly and arresting cell division at metaphase. Also stimulates platelet release from megakaryocytes.
VESICANT — perivascular extravasation causes severe tissue necrosis. Administer only IV (never IM or SC). Myelosuppression (nadir 4-7 days). Peripheral neuropathy. Also used to treat immune-mediated thrombocytopenia (platelet stimulation).
Species-specific contraindications and adverse-reaction reports for dog may differ from canine / feline reference data — consult the primary citations listed with each rule.
Why a species-specific page? Vincristine pharmacokinetics differ across species: dose ranges, intervals, and route preferences are not interchangeable. Cross-extrapolation from canine doses is unsafe in dog — the rules above are the citations specific to this species, not generic recommendations.
Sourced from published veterinary references; awaiting credentialed clinical reviewer. See our editorial process. Reference only — not veterinary advice.