Dog · Canis lupus familiaris · typical adult weight 2.00–80.00 kg
Vincristine is dosed at 0.5–0.7 mg/m2 IV Weekly per protocol in dogs, per *References 1, 2, 11-13, 42, 51-55. — 1. Rogers KS: Transmissible venereal tumor, Compend Contin Educ Pract Vet 19:1036-1045, 1997. / 2. Das U, Das AK: Review of canine transmissible venereal sarcoma, Vet Res Comm 24:545-556, 2000. — Verified against Withrow & MacEwen's Small Animal Clinical Oncology, 5th Ed, p.708 (2026-08-01). — LOCATOR CONVENTION 2026-08-07: the bare 'p.708' in this citation is the PDF index of the held scan, not the printed page. The PRINTED page is p.694; verified by finding the drug named there. If you are holding the book, turn to p.694. — SOURCE EDITION: Withrow and MacEwen's Small Animal Clinical Oncology — ISBN 9781437723625, https://openlibrary.org/isbn/9781437723625. Vincristine is used in dogs for Lymphoma (CHOP protocol), immune-mediated thrombocytopenia. Routes documented in dogs: IV. A typical adult dog weighs 2.00–80.00 kg. ExoticRx lists 1 cited dose rule for Vincristine in dogs, drawn from published veterinary references. Verify against current literature before clinical use.
US trade names: Oncovin
| Route | Dose | Frequency | Duration | Indication | Evidence | Source |
|---|---|---|---|---|---|---|
| IV | 0.5–0.7 mg/m2 | Weekly per protocol | Per chemotherapy protocol | Lymphoma (CHOP protocol), immune-mediated thrombocytopenia | Strong | *References 1, 2, 11-13, 42, 51-55. — 1. Rogers KS: Transmissible venereal tumor, Compend Contin Educ Pract Vet 19:1036-1045, 1997. / 2. Das U, Das AK: Review of canine transmissible venereal sarcoma, Vet Res Comm 24:545-556, 2000. — Verified against Withrow & MacEwen's Small Animal Clinical Oncology, 5th Ed, p.708 (2026-08-01). — LOCATOR CONVENTION 2026-08-07: the bare 'p.708' in this citation is the PDF index of the held scan, not the printed page. The PRINTED page is p.694; verified by finding the drug named there. If you are holding the book, turn to p.694. — SOURCE EDITION: Withrow and MacEwen's Small Animal Clinical Oncology — ISBN 9781437723625, https://openlibrary.org/isbn/9781437723625 |
Every held source for this drug and species, as printed. Where they differ, both are shown — the choice is yours, not ours.
The sources disagree for this combination. The ranges below do not overlap on a comparable route. This is not an error in one of them — published veterinary references differ, and reconciling them for a particular patient is a clinical judgement.
| Dose (mg/kg) | Route | Source | As printed |
|---|---|---|---|
| 0.02 | IV | BSAVA Small Animal Formulary, 10th ed — Part A (Canine and Feline)p.441 | 0.02 mg/kg i.v. once (limited reports of the use of vincristine to raise circulating plat |
| 0.025–0.05 | IV | Papich Saunders Handbook of Veterinary Drugs, 4th edp.869 | • Antitumor: 0.5-0.75 mg/m2 IV (or 0.025-0.05 mg/kg) once/week. |
| 0.02 | IV | Papich Saunders Handbook of Veterinary Drugs, 4th edp.869 | • Thrombocytopenia: 0.02 mg/kg IV once/week (with prednisolone). |
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Binds tubulin, inhibiting microtubule assembly and arresting cell division at metaphase. Also stimulates platelet release from megakaryocytes.
VESICANT — perivascular extravasation causes severe tissue necrosis. Administer only IV (never IM or SC). Myelosuppression (nadir 4-7 days). Peripheral neuropathy. Also used to treat immune-mediated thrombocytopenia (platelet stimulation).
Species-specific contraindications and adverse-reaction reports for dogs may differ from canine / feline reference data — consult the primary citations listed with each rule.
Vincristine dose range in dogs, with cited source references: IV 0.5–0.7 mg/m2 Weekly per protocol. Reference ranges from cited sources — verify against current literature before clinical use.
Documented routes for Vincristine in dogs: IV.
Cited course lengths for Vincristine in dogs include: Per chemotherapy protocol. Duration depends on the indication — match it to the specific dose rule in the table above.
Vincristine is indicated in dogs for: Lymphoma (CHOP protocol), immune-mediated thrombocytopenia.
These are general warnings for Vincristine across species; consult the dog dosing table above for species-specific guidance. VESICANT — perivascular extravasation causes severe tissue necrosis. Administer only IV (never IM or SC). Myelosuppression (nadir 4-7 days). Peripheral neuropathy. Also used to treat immune-mediated thrombocytopenia (platelet stimulation).
Why a species-specific page? Vincristine pharmacokinetics differ across species: dose ranges, intervals, and route preferences are not interchangeable. Cross-extrapolation from canine doses is unsafe in dogs — the rules above are the citations specific to this species, not generic recommendations.
Sourced from published veterinary references; awaiting credentialed clinical reviewer. See our editorial process. Reference only — not veterinary advice.
| Dose (mg/m2) | Route | Source | As printed |
|---|
| 0.5–0.75 | IV | Papich Saunders Handbook of Veterinary Drugs, 4th edp.869 | • Antitumor: 0.5-0.75 mg/m2 IV (or 0.025-0.05 mg/kg) once/week. |
Figures are transcribed from the cited page or table of each held edition and are shown for reference only. They are not dose recommendations, they do not feed the calculator, and none has been reviewed by a veterinarian.