ExoticRx · exoticrx.com/drugs/cimetidine
US brand names:Tagamet
Cimetidine is dosed at 5–10 mg/kg PO q6-12h in rabbits, per Carpenter's Exotic Animal Formulary, 6th Ed. Verify against current literature before clinical use.
Competitively blocks histamine H2 receptors on parietal cells, reducing basal and stimulated gastric acid secretion.
Inhibits cytochrome P450 enzymes (many drug interactions — theophylline, benzodiazepines, etc.). Less potent than famotidine. Gynecomastia with chronic use in humans. Give 30 min before meals.
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