Dog · Canis lupus familiaris · typical adult weight 2.00–80.00 kg
Fludarabine is used in dog for Low-grade lymphoma / CLL (investigational). Routes documented in dog: IV. A typical adult dog weighs 2.00–80.00 kg. ExoticRx lists 1 cited dose rule for Fludarabine in dog, drawn from published veterinary references. Verify against current literature before clinical use.
Trade names: Fludara
| Route | Dose | Frequency | Duration | Indication | Evidence | Source |
|---|---|---|---|---|---|---|
| IV | 15–25 mg/kg | 15-25mg/m2 IV over 30 min q24h x 5 days, q28 days | Monitor CBC — severe immunosuppression | Low-grade lymphoma / CLL (investigational) | Anecdotal | Withrow & MacEwen's Small Animal Clinical Oncology, 6th Ed |
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Fluorinated nucleotide analogue of vidarabine. Inhibits DNA polymerase alpha, ribonucleotide reductase, and DNA primase. Induces apoptosis in lymphoid cells.
Severe immunosuppression — risk of opportunistic infections. Autoimmune hemolytic anemia. Neurotoxicity at high doses. Limited veterinary data for indolent lymphoid neoplasms.
Species-specific contraindications and adverse-reaction reports for dog may differ from canine / feline reference data — consult the primary citations listed with each rule.
Why a species-specific page? Fludarabine pharmacokinetics differ across species: dose ranges, intervals, and route preferences are not interchangeable. Cross-extrapolation from canine doses is unsafe in dog — the rules above are the citations specific to this species, not generic recommendations.
Sourced from published veterinary references; awaiting credentialed clinical reviewer. See our editorial process. Reference only — not veterinary advice.