Dog · Canis lupus familiaris · typical adult weight 2.00–80.00 kg
Imatinib is dosed at 5–10 mg/kg PO q24h in dogs, per Withrow & MacEwen's Small Animal Clinical Oncology, 6th Ed. Imatinib is used in dogs for Mast cell tumors (c-KIT mutant). Routes documented in dogs: PO. A typical adult dog weighs 2.00–80.00 kg. ExoticRx lists 1 cited dose rule for Imatinib in dogs, drawn from published veterinary references. Verify against current literature before clinical use.
US trade names: Gleevec
| Route | Dose | Frequency | Duration | Indication | Evidence | Source |
|---|---|---|---|---|---|---|
| PO | 5–10 mg/kg | q24h | Chronic use until progression or intolerance | Mast cell tumors (c-KIT mutant) | Moderate | Withrow & MacEwen's Small Animal Clinical Oncology, 6th Ed |
Need the exact dose for your patient?
These ranges are per kg. Enter your dog's weight to get the precise dose and draw-up volume — unit and concentration math done for you.
Selectively inhibits BCR-ABL, c-KIT, and PDGFR tyrosine kinases. Blocks signaling pathways involved in cell proliferation and survival in KIT-mutant tumors.
Hepatotoxicity — monitor liver enzymes. GI upset, edema, and myelosuppression possible. Used for mast cell tumors and GIST in dogs. Expensive.
Species-specific contraindications and adverse-reaction reports for dogs may differ from canine / feline reference data — consult the primary citations listed with each rule.
Imatinib dose range in dogs, with cited source references: PO 5–10 mg/kg q24h. Reference ranges from cited sources — verify against current literature before clinical use.
Documented routes for Imatinib in dogs: PO.
Cited course lengths for Imatinib in dogs include: Chronic use until progression or intolerance. Duration depends on the indication — match it to the specific dose rule in the table above.
Imatinib is indicated in dogs for: Mast cell tumors (c-KIT mutant).
These are general warnings for Imatinib across species; consult the dog dosing table above for species-specific guidance. Hepatotoxicity — monitor liver enzymes. GI upset, edema, and myelosuppression possible. Used for mast cell tumors and GIST in dogs. Expensive.
Why a species-specific page? Imatinib pharmacokinetics differ across species: dose ranges, intervals, and route preferences are not interchangeable. Cross-extrapolation from canine doses is unsafe in dogs — the rules above are the citations specific to this species, not generic recommendations.
Sourced from published veterinary references; awaiting credentialed clinical reviewer. See our editorial process. Reference only — not veterinary advice.