Dog · Canis lupus familiaris · typical adult weight 2.00–80.00 kg
Irinotecan is used in dog for Colorectal carcinoma / lymphoma, Brain tumors (investigational, CNS penetration). Routes documented in dog: IV. A typical adult dog weighs 2.00–80.00 kg. ExoticRx lists 2 cited dose rules for Irinotecan in dog, drawn from published veterinary references. Verify against current literature before clinical use.
Trade names: Camptosar
| Route | Dose | Frequency | Duration | Indication | Evidence | Source |
|---|---|---|---|---|---|---|
| IV | 80–120 mg/kg | 80-120mg/m2 IV over 90 min q14-21 days | Premedicate with atropine for early diarrhea | Colorectal carcinoma / lymphoma | Weak | Withrow & MacEwen's Small Animal Clinical Oncology, 6th Ed |
| IV | 60–80 mg/kg | 60-80mg/m2 IV over 90 min q14 days | Monitor for delayed diarrhea and myelosuppression | Brain tumors (investigational, CNS penetration) | Anecdotal | Withrow & MacEwen's Small Animal Clinical Oncology, 6th Ed |
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These ranges are per kg. Enter your dog's weight to get the precise dose and draw-up volume — unit and concentration math done for you.
Prodrug converted by carboxylesterases to active metabolite SN-38, which inhibits topoisomerase I. SN-38 is 100-1000x more potent than parent compound.
Early and late diarrhea syndromes. Early: cholinergic (treat with atropine). Late: secretory (potentially fatal). Myelosuppression. Atropine pretreatment recommended in dogs.
Species-specific contraindications and adverse-reaction reports for dog may differ from canine / feline reference data — consult the primary citations listed with each rule.
Why a species-specific page? Irinotecan pharmacokinetics differ across species: dose ranges, intervals, and route preferences are not interchangeable. Cross-extrapolation from canine doses is unsafe in dog — the rules above are the citations specific to this species, not generic recommendations.
Sourced from published veterinary references; awaiting credentialed clinical reviewer. See our editorial process. Reference only — not veterinary advice.