Dog · Canis lupus familiaris · typical adult weight 2.00–80.00 kg
Mechlorethamine is used in dog for Lymphoma (MOPP protocol component), Cutaneous epitheliotropic lymphoma. Routes documented in dog: IV, Topical. A typical adult dog weighs 2.00–80.00 kg. ExoticRx lists 2 cited dose rules for Mechlorethamine in dog, drawn from published veterinary references. Verify against current literature before clinical use.
Trade names: Mustargen
| Route | Dose | Frequency | Duration | Indication | Evidence | Source |
|---|---|---|---|---|---|---|
| IV | 3 mg/kg | 3mg/m2 IV on days 1 and 8 of 28-day cycle | Verify IV placement — severe vesicant | Lymphoma (MOPP protocol component) | Moderate | Withrow & MacEwen's Small Animal Clinical Oncology, 6th Ed |
| Topical | 0 mg/kg | Apply 10-20mg/dL solution to lesions q24h | Chronic use; monitor for skin irritation | Cutaneous epitheliotropic lymphoma | Moderate | Withrow & MacEwen's Small Animal Clinical Oncology, 6th Ed |
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These ranges are per kg. Enter your dog's weight to get the precise dose and draw-up volume — unit and concentration math done for you.
Bifunctional alkylating agent that forms inter-strand DNA cross-links, preventing DNA strand separation and replication. Highly reactive — acts within minutes.
Severe vesicant — extravasation is a medical emergency. Potent myelosuppression. Strong emetogen. Used in MOPP protocol for lymphoma and topically for cutaneous lymphoma.
Species-specific contraindications and adverse-reaction reports for dog may differ from canine / feline reference data — consult the primary citations listed with each rule.
Why a species-specific page? Mechlorethamine pharmacokinetics differ across species: dose ranges, intervals, and route preferences are not interchangeable. Cross-extrapolation from canine doses is unsafe in dog — the rules above are the citations specific to this species, not generic recommendations.
Sourced from published veterinary references; awaiting credentialed clinical reviewer. See our editorial process. Reference only — not veterinary advice.