Dog · Canis lupus familiaris · typical adult weight 2.00–80.00 kg
Mesna is used in dog for Hemorrhagic cystitis prevention with ifosfamide, Hemorrhagic cystitis prevention (oral alternative). Routes documented in dog: IV, PO. A typical adult dog weighs 2.00–80.00 kg. ExoticRx lists 2 cited dose rules for Mesna in dog, drawn from published veterinary references. Verify against current literature before clinical use.
Trade names: Mesnex
| Route | Dose | Frequency | Duration | Indication | Evidence | Source |
|---|---|---|---|---|---|---|
| IV | 20 mg/kg | Equal mg dose at 0, 4, 8h post-ifo | Every ifosfamide administration | Hemorrhagic cystitis prevention with ifosfamide | Strong | Withrow & MacEwen's Small Animal Clinical Oncology, 6th Ed |
| PO | 40 mg/kg | 2x IV dose at 0, 2, 6h post-alkylator | Every ifosfamide or high-dose CTX administration | Hemorrhagic cystitis prevention (oral alternative) | Moderate | Withrow & MacEwen's Small Animal Clinical Oncology, 6th Ed |
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These ranges are per kg. Enter your dog's weight to get the precise dose and draw-up volume — unit and concentration math done for you.
Thiol compound that binds and inactivates acrolein (toxic metabolite of cyclophosphamide and ifosfamide) in the urine, preventing hemorrhagic cystitis.
Always co-administer with ifosfamide. Also used with high-dose cyclophosphamide. Does not affect antitumor activity. GI upset with oral form. Given at 0, 4, and 8 hours after alkylating agent.
Species-specific contraindications and adverse-reaction reports for dog may differ from canine / feline reference data — consult the primary citations listed with each rule.
Why a species-specific page? Mesna pharmacokinetics differ across species: dose ranges, intervals, and route preferences are not interchangeable. Cross-extrapolation from canine doses is unsafe in dog — the rules above are the citations specific to this species, not generic recommendations.
Sourced from published veterinary references; awaiting credentialed clinical reviewer. See our editorial process. Reference only — not veterinary advice.